Search found 406 matches

by stjohnh
Sat Feb 24, 2018 9:39 pm
Forum: General Topics: RLS/WED
Topic: Sleep monitor
Replies: 21
Views: 1810

Re: Sleep monitor

Do you have some data on how to distinguish between sleep and being awake?.... [/quote] I don't have any data on determining awake versus being asleep, however heart rate by itself is not likely to be very good for that, since meditating or relaxing can produce a fairly low steady heart rate and st...
by stjohnh
Fri Feb 23, 2018 5:02 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 71
Views: 922

Re: Dipyridamole

Picking up the baton somewhat, I had my first night of dipyridamole last night.... Legs, I'd be interested to know if you have the same experience I do with dipyridamole alone. The particular thing I was wondering about is do you have a 30-minute spell of sleepiness starting approximately 45 minute...
by stjohnh
Fri Feb 23, 2018 4:56 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 71
Views: 922

Re: Dipyridamole

Assuming us early adopters continue to have some beneficial effect from dipyridamole, I expect that as soon as the paper describing the 13 person trial that was mentioned in the adenosine paper comes out, that it will be much easier for others that want to try dipyridamole to persuade their doctors ...
by stjohnh
Fri Feb 23, 2018 1:12 am
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 71
Views: 922

Re: Dipyridamole

Well, I now have been using dipyridamole for a month. The first 10 days were pretty awful as I was taking too high a dose and the results were somewhat like augmentation or withdrawal from a dopamine agonist. I tried going completely without the pramipexole and that really didn't work, and so I'm st...
by stjohnh
Tue Feb 20, 2018 11:29 pm
Forum: General Topics: RLS/WED
Topic: Sleep monitor
Replies: 21
Views: 1810

Re: Sleep monitor

I have been experimenting with medications over the past couple of weeks in attempts to get better control of my restless leg syndrome, insomnia, and malaise. That has rekindled my interest in having a better measure of deep sleep rather than how I feel the next day, which at best can be classified ...
by stjohnh
Mon Feb 19, 2018 12:24 am
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 71
Views: 922

Re: Dipyridamole

... So, I can count out the idea of getting any benefit from the iron IVs that have helped so many. ... Well, it's not inconceivable that an intrathecal iron preparation could be developed that could be injected into the spinal column, bypassing the blood-brain barrier. And yes, my comment about ne...
by stjohnh
Sun Feb 18, 2018 10:01 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 71
Views: 922

Re: Dipyridamole

Wouldn't it be more likely that the initial sleepiness is due to the spike in adenosine, whose role in wake/sleep is to cause a feeling of sleepiness as the concentration builds?... That is part of why I feel that this solution is so elegant. It helps return our neurtransmitter chemistry to somethi...
by stjohnh
Sun Feb 18, 2018 8:19 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 71
Views: 922

Re: Dipyridamole

Legs. Great that you managed to get a prescription for dipyridamole. I think that it is unknown what is the appropriate dose for an individual. As others have pointed out, brain iron levels may be an important consideration as to what dose is needed. It appears as though I am more sensitive to the d...
by stjohnh
Sun Feb 18, 2018 6:56 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 71
Views: 922

Re: Dipyridamole

I havne't thought carefully but - could it be that the sleepiness induced by the dipyridamole triggers the urge to move? When we're alert, the urge might be there in the background even though it doesn't really bother us, but if we relax (lie down, take a sleeping pill, whatever), it flares up. Thi...
by stjohnh
Sun Feb 18, 2018 6:47 pm
Forum: Prescription Medications
Topic: gabapentin and anger
Replies: 4
Views: 60

Re: gabapentin and anger

Gabapentin has a variety of psychiatric side effects, depression is among the most common and some of your symptoms could be signs of depression. Horizant is really a different form of gabapentin and would have no difference in side effects. Probably the best thing you should do is to call your doct...
by stjohnh
Sun Feb 18, 2018 6:45 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 13
Views: 120

Re: Discussion of Adenosine paper

I do understand that it's very difficult to get an animal model for urge to move symptoms. However, some of the authors are among the best known RLS researchers. I have a hard time believing that they really don't understand that urge to move is different than PLMS.
by stjohnh
Wed Feb 14, 2018 2:06 am
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 71
Views: 922

Re: Dipyridamole

Over the past couple of days I've tried to pay more attention to the exact timing and effects of taking the 75 mg tablet of dipyridamole. I seem to consistently get a 30 minute spell of sleepiness starting almost exactly 45 minutes after taking the tablet. Starting approximately 75 minutes after tak...
by stjohnh
Wed Feb 14, 2018 1:59 am
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 71
Views: 922

Re: Dipyridamole

Interesting eye applications, mostly for ophthalmic circulatory problems were discussing an article I just read about that.
by stjohnh
Tue Feb 13, 2018 3:42 pm
Forum: Just Joined?
Topic: Just joined
Replies: 47
Views: 708

Re: Just joined

It was the knee pain rather than RLS/WED that kept Edith from having a good night rest but it didn't bother me too much even though I am still tired. We did try Tylenol extra strength. It probable did help somewhat. I'll be setting up a DR's appointment this morning to check this out. The red feath...
by stjohnh
Mon Feb 12, 2018 7:47 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 13
Views: 120

Re: Discussion of Adenosine paper

This is a helpful article for those interested in how adenosine works in the sleep cycle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769007/

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