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by stjohnh
Sun Feb 18, 2018 10:01 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 62
Views: 711

Re: Dipyridamole

Wouldn't it be more likely that the initial sleepiness is due to the spike in adenosine, whose role in wake/sleep is to cause a feeling of sleepiness as the concentration builds?... That is part of why I feel that this solution is so elegant. It helps return our neurtransmitter chemistry to somethi...
by stjohnh
Sun Feb 18, 2018 8:19 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 62
Views: 711

Re: Dipyridamole

Legs. Great that you managed to get a prescription for dipyridamole. I think that it is unknown what is the appropriate dose for an individual. As others have pointed out, brain iron levels may be an important consideration as to what dose is needed. It appears as though I am more sensitive to the d...
by stjohnh
Sun Feb 18, 2018 6:56 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 62
Views: 711

Re: Dipyridamole

I havne't thought carefully but - could it be that the sleepiness induced by the dipyridamole triggers the urge to move? When we're alert, the urge might be there in the background even though it doesn't really bother us, but if we relax (lie down, take a sleeping pill, whatever), it flares up. Thi...
by stjohnh
Sun Feb 18, 2018 6:47 pm
Forum: Prescription Medications
Topic: gabapentin and anger
Replies: 1
Views: 12

Re: gabapentin and anger

Gabapentin has a variety of psychiatric side effects, depression is among the most common and some of your symptoms could be signs of depression. Horizant is really a different form of gabapentin and would have no difference in side effects. Probably the best thing you should do is to call your doct...
by stjohnh
Sun Feb 18, 2018 6:45 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 12
Views: 71

Re: Discussion of Adenosine paper

I do understand that it's very difficult to get an animal model for urge to move symptoms. However, some of the authors are among the best known RLS researchers. I have a hard time believing that they really don't understand that urge to move is different than PLMS.
by stjohnh
Wed Feb 14, 2018 2:06 am
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 62
Views: 711

Re: Dipyridamole

Over the past couple of days I've tried to pay more attention to the exact timing and effects of taking the 75 mg tablet of dipyridamole. I seem to consistently get a 30 minute spell of sleepiness starting almost exactly 45 minutes after taking the tablet. Starting approximately 75 minutes after tak...
by stjohnh
Wed Feb 14, 2018 1:59 am
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 62
Views: 711

Re: Dipyridamole

Interesting eye applications, mostly for ophthalmic circulatory problems were discussing an article I just read about that.
by stjohnh
Tue Feb 13, 2018 3:42 pm
Forum: Just Joined?
Topic: Just joined
Replies: 47
Views: 523

Re: Just joined

It was the knee pain rather than RLS/WED that kept Edith from having a good night rest but it didn't bother me too much even though I am still tired. We did try Tylenol extra strength. It probable did help somewhat. I'll be setting up a DR's appointment this morning to check this out. The red feath...
by stjohnh
Mon Feb 12, 2018 7:47 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 12
Views: 71

Re: Discussion of Adenosine paper

This is a helpful article for those interested in how adenosine works in the sleep cycle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769007/
by stjohnh
Mon Feb 12, 2018 7:04 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 12
Views: 71

Re: Discussion of Adenosine paper

Here's a question that's been bothering me about the adenosine paper. The very first sentence says "the symptomatology of restless leg syndrome includes periodic leg movements during sleep PLMS, dysesthesias, and hyperarousal." During the rest of the paper there are frequent references to ...
by stjohnh
Sun Feb 11, 2018 10:21 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 62
Views: 711

Re: Dipyridamole

Now that I am getting several days experience using a combination of 112.5 mg dipyridamole + 0.0625 mg of pramipexole I am starting to notice some details. I have been taking the initial 75mg of dipyridamole at 6 p.m. and the pramipexole at 7:30 pm I am having mild urge to move symptoms by 6 p.m., t...
by stjohnh
Sun Feb 11, 2018 8:45 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 62
Views: 711

Re: Dipyridamole

... So I guess it raises the question of whether the opioid causes the hyperarousal for us or it the opioid just treats the movement issues and leaves us with hyperglutamate induced insomnia because the opioid only treats the hyperdopamine side of RLS. That's what I had been starting to think, that...
by stjohnh
Sun Feb 11, 2018 3:25 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 12
Views: 71

Re: Dipyridamole

...the strong hyperarousal problem didn't happen until after I started hydromorphone. (I had been on codeine before that, but I don't know if my hyperarousal was bad then, because my symptoms were so godawful I couldn't tell.) Either the progressing disease or the use of opioids precipitated the st...
by stjohnh
Sat Feb 10, 2018 9:15 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 12
Views: 71

Discussion of Adenosine paper

Steve, read Beth's post from February 7th, and tell me if that all fits together. It's only been the last 36 hours that my sleeping has improved enough so that I can even start to think about rereading the article. I have several other things that I am obligated to do before I can do that. The last ...
by stjohnh
Fri Feb 09, 2018 6:37 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 62
Views: 711

Re: Dipyridamole

WOW! Last night was pretty remarkable. This will probably be a somewhat long post so the punchline first and then those that want to can read the details. Last night I took 112.5 mg of dipyridamole. I then SAT for 3 hours watching the Olympics. I have not felt quite so normal for at least 5 and poss...

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