Restless Legs Syndrome (RLS) Discussion Board

Paul, I am here but generally not posting. I have developed MCI (Mild Cognitive Impairment) and so don't want to give bad advice. The best recommendation I have is to see if you can get IV Iron, preferably Injectafer, if you haven't. If you want to go the dipyridamole route, you will need a prescrip...

Well, there is lots in the "Published Research" section of this forum

viewtopic.php?f=5&t=4749

If you want to know about what studies are in progress now (I.E. Data has not been fully collected and reports have not been published):
https://clinicaltrials.gov/

Most likely from Horizant. Going off the Neupro doesn't cause this. Sleepiness is the most common side effect and the prescribing info says it occurs in at least 10%. It may diminish with time, or you can use a lower dose.

Do what Steve said.

Doesn't seem to make my RLS worse. Though what about gabapentin? It is commonly used for neuropathic pain AND it treats RLS...

Hmmm... I'll see what I can find.

I augmented about 4 years ago on 0.375 mg pramipexole, got off it (one of the most memorable and awful experiences of my life) and stayed off it for a few months. I was subsequently able to restart pramipexole at 0.0625mg daily (one half of the smallest size tablet). It helped a lot, and I never had...

Well, I continue to suffer considerably, even though I am MUCH better with IV iron as my main RLS treatment. Basically, I have to take medicine to sleep, awake slightly less tired than when I went to sleep. I am ok (NOT "good") from 6am to about noon and then deteriorate steadily until I go to sleep...

Subjective sleep quality improved, but the proxy I was using for deep sleep (heart rate variability) didn't change much. But the only real way to check is with a brain wave study (dedicated EEG type sleep instrument, formal sleep study, etc.) The big improvement was in a feeling of well being during...

Good luck. It usually takes a few weeks for IV iron to have and effect.

The question of iron levels is one that is exceedingly complex, as Holland's second reference points out. ... And if only there were a way to elevate brain iron for those of us with the combination of high ferritin and severe RLS. Before I got my IV iron infusions I tried several things, the nails ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890889/ This article reviews the multiple functions of ferritin, with careful explanations of how they work. https://www.sciencedirect.com/science/article/pii/S0006497120608254?via%3Dihub This one also is a general article on the many things (besides ir...

Hi Maulsby, I'm glad you found our group, hopefully you can get some good information. There are two issues in your post that I'd like to address: First, 2.5 mg of pramipexole is a VERY high dose, well above the acceptable range of treatment for RLS. At that dose, you have almost certainly augmented...

I'm so sorry.

I don't have any experience with this, but the International Restless Legs Syndrome Study Group guidelines paper says in part 5.4.1 that iron sucrose "is probably not effective." If possible, it is probably best to use Injectafer (ferric carboxymaltose). If not available or too expensive, the best e...