Search found 395 matches

by stjohnh
Wed Feb 14, 2018 2:06 am
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 56
Views: 675

Re: Dipyridamole

Over the past couple of days I've tried to pay more attention to the exact timing and effects of taking the 75 mg tablet of dipyridamole. I seem to consistently get a 30 minute spell of sleepiness starting almost exactly 45 minutes after taking the tablet. Starting approximately 75 minutes after tak...
by stjohnh
Wed Feb 14, 2018 1:59 am
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 56
Views: 675

Re: Dipyridamole

Interesting eye applications, mostly for ophthalmic circulatory problems were discussing an article I just read about that.
by stjohnh
Tue Feb 13, 2018 3:42 pm
Forum: Just Joined?
Topic: Just joined
Replies: 47
Views: 448

Re: Just joined

It was the knee pain rather than RLS/WED that kept Edith from having a good night rest but it didn't bother me too much even though I am still tired. We did try Tylenol extra strength. It probable did help somewhat. I'll be setting up a DR's appointment this morning to check this out. The red feath...
by stjohnh
Mon Feb 12, 2018 7:47 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 10
Views: 57

Re: Discussion of Adenosine paper

This is a helpful article for those interested in how adenosine works in the sleep cycle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769007/
by stjohnh
Mon Feb 12, 2018 7:04 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 10
Views: 57

Re: Discussion of Adenosine paper

Here's a question that's been bothering me about the adenosine paper. The very first sentence says "the symptomatology of restless leg syndrome includes periodic leg movements during sleep PLMS, dysesthesias, and hyperarousal." During the rest of the paper there are frequent references to ...
by stjohnh
Sun Feb 11, 2018 10:21 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 56
Views: 675

Re: Dipyridamole

Now that I am getting several days experience using a combination of 112.5 mg dipyridamole + 0.0625 mg of pramipexole I am starting to notice some details. I have been taking the initial 75mg of dipyridamole at 6 p.m. and the pramipexole at 7:30 pm I am having mild urge to move symptoms by 6 p.m., t...
by stjohnh
Sun Feb 11, 2018 8:45 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 56
Views: 675

Re: Dipyridamole

... So I guess it raises the question of whether the opioid causes the hyperarousal for us or it the opioid just treats the movement issues and leaves us with hyperglutamate induced insomnia because the opioid only treats the hyperdopamine side of RLS. That's what I had been starting to think, that...
by stjohnh
Sun Feb 11, 2018 3:25 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 10
Views: 57

Re: Dipyridamole

...the strong hyperarousal problem didn't happen until after I started hydromorphone. (I had been on codeine before that, but I don't know if my hyperarousal was bad then, because my symptoms were so godawful I couldn't tell.) Either the progressing disease or the use of opioids precipitated the st...
by stjohnh
Sat Feb 10, 2018 9:15 pm
Forum: Prescription Medications
Topic: Discussion of Adenosine paper
Replies: 10
Views: 57

Discussion of Adenosine paper

Steve, read Beth's post from February 7th, and tell me if that all fits together. It's only been the last 36 hours that my sleeping has improved enough so that I can even start to think about rereading the article. I have several other things that I am obligated to do before I can do that. The last ...
by stjohnh
Fri Feb 09, 2018 6:37 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 56
Views: 675

Re: Dipyridamole

WOW! Last night was pretty remarkable. This will probably be a somewhat long post so the punchline first and then those that want to can read the details. Last night I took 112.5 mg of dipyridamole. I then SAT for 3 hours watching the Olympics. I have not felt quite so normal for at least 5 and poss...
by stjohnh
Thu Feb 08, 2018 9:52 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 56
Views: 675

Re: Dipyridamole

Beth, yes, my inclination, if no sleep by midnight, is to take 0.0625 mg of pramipexole.
by stjohnh
Thu Feb 08, 2018 8:01 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 56
Views: 675

Re: Dipyridamole

... you said that the NIH test started at 100 mg then went to 200 and then 400 with patients who were not being treated otherwise. That suggests to me that , on average ,100mg wasn't enough and that 400 was probably didn't provide any added benefit or made things worse... The dipyridamole trial was...
by stjohnh
Thu Feb 08, 2018 7:50 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 56
Views: 675

Re: Dipyridamole

:shock: I want a stem cell injection today that fixes my faulty DNA and corrects the faulty serum-to-brain iron transport.

How about an app that shows your brain iron level when you hold your phone up to your ear?
by stjohnh
Thu Feb 08, 2018 5:18 pm
Forum: Prescription Medications
Topic: Dipyridamole
Replies: 56
Views: 675

Re: Dipyridamole

Betty, The 1/2 life for initial decline from peak for dipyridamole is 40 minutes. Terminal decline is 10 hours. So on the basis of half life the dose I took the night before last of 375 mg should be mostly gone by the time I took last night's dose of 225mg. The fact that my urge to move was still co...
by stjohnh
Thu Feb 08, 2018 2:41 pm
Forum: General Topics: RLS/WED
Topic: I found an easy to understand book on sleep!!
Replies: 4
Views: 65

I found an easy to understand book on sleep!!

I have been seriously sleep-deprived over the past week or 10 days due to attempts at adjusting my medications to get better sleep. This has left my brain completely foggy pretty much 24/7. I recently found a book on sleep that I can still understand even with my foggy brain. The URL for the book on...

Go to advanced search