Restless Legs Syndrome (RLS) Discussion Board

Research into brain iron regulation in RLS seems to drop off a cliff in mid 2010’s. Any insight on what happened?

Did they think it was a dead-end?

Rustsmith - you are probably the only one reading this. Any insight?

Thank you rustsmith. After further research, I’m finding that this is actually not the case and my initial thesis was very much incorrect. Although some people could respond to iron for longer, it’s probably very small subset of people.

There is a lot wrong in the RLS brain. It may even be that the ...

Why don’t they give additional iron to non-responders? There doesn’t seem to be any scientific rationale as to why a second dose of iron isn’t given, or a third. Based on my understanding, it’s due to safety concerns which are incomplete and outdated. We really don’t understand the boundaries of ...

I developed augmentation in another part of my brain. I.e, The pathological presentation of augmentation occurred in another part of my brain. It presented as a constant hyperarousal which prevents me from sleeping. My akathisia was entirely controlled, but I could not sleep. It was not “alerting ...

What is your status now? Did your new drug work?

I figured out what caused this for me so I will update this post in case anyone else experiences this.

D1 super sensitivity. I basically developed augmentation in another part of my brain, most likely the nucleus acumben.

I was able to counteract the hyperarousal I was experience from any ...

I’ve read several accounts online of people developing tolerance to this drug over time. Not complete loss of efficacy but some loss. Please be aware of this going into it. Start slow and use breaks.

It definitely works for RLS, but there is a ceiling on how much it increases dopamine. I can’t opine on whether or not it causes augmentations, but the MOA very much leads me to believe it doesn’t cause augmentation. It’s not prescribed for RLS because it’s a dirty drug, it’s not fully understood ...

It’s not unheard of, it’s just not documented well in the scientific literature. I augmented on opioids as have a few others… I don’t think augmentation is the right word for these cases, it’s better defined as building tolerance which “shouldn’t happen”. Men with early onset RLS seem to have the ...

Buprenoprhine can cause insomnia. If that happens try taking it earlier in the day. And, give it 2-4 weeks to wear off.

I have a new pain Doctor. I've had her less than a year. She never asked me about my history. She just took over from the previous doctor I had started with since moving to Albuquerque. The first injection she did was in the right spot, last summer.
I had sent her a note that my RLS had returned ...

So, you are combining it with opioids? It’s additive effect is helping your sleep? If so, there are some papers supporting the use of Abilify with opioids to mitigate some of the adverse dopamine effects.

I am probably not the best example since I’m a .0001%

I’m going to ask my doctor to prescribe ...

I posted a research paper indicating abilify for augmentation. Here it is https://pubmed.ncbi.nlm.nih.gov/3781817 ... mentation.

Unfortunately, I’m having to use similar techniques because the medications don’t work for me anymore. After putting in the effort, it is more effective than I expected.

I primarily get RLS in either my left or right scapula. The tens unit can eliminate these symptoms 100% consistently, and I ...

https://www.forbes.com/sites/williamhaseltine/2024/01/19/combating-alzheimers-with-focused-ultrasound-drug-delivery/amp/

I saw this on 60 minutes as well. They are using ultrasound to temporarily increase the porosity of the BBb to deliver medicine to certain areas of the brain. I’m sure there is a ...