Restless Legs Syndrome (RLS) Discussion Board

Fascinating. Adenosine reuptake inhibition. A magic bullet ahead? Thanks, Steve.

Yes, very complex. Glutamate pathway is the up regulator. All of these come down to the synapses, either at the releasing end or the receptor end. GABA is the main downregulator pathway, and it certainly must be involved in some way, also. The main thing is that RLS is a physiologic disease, despite ...

I'm new on this forum but also a 65 year sufferer of RLS. I know a few things that might be interesting to you. Opioid addiction and other addictions are related to some defect in the pathway in the nervous system called the "dopaminergic pathway" that uses dopamine as the neurotransmitter. It is ...

There is a link seen between iron deficiency and RLS in the latest medical literature. Whether there is a cause/effect relationship is anyone's guess. Maybe people with iron deficiency and concurrent RLS is just the result of lack of sleep resulting in poor diet. Just not known. My RLS is pretty ...

I'm guessing that the running with stretches did delay the progression of it. I used to swim a mile per day, and my RLS continued slowly worsening in frequency. It was only the stretches each day beginning after my valve surgery in 2012 that it began to get better and better, As you mentioned, if it ...

I am new to this forum. This post is obviously anecdotal and might be unique to me, but after 65 years of RLS beginning at age 11 and slowly progressing, I am astonished at the effectiveness of this non-medication treatment that I learned not from treatment for RLS, but in the course of rehab from ...