Restless Legs Syndrome (RLS) Discussion Board

Personally I would be surprised if Naltrexone is more effective than placebo for the average patient but you never know how it will work in an individual case. However given what we know about how opioids affect RLS, it is unlikely Naltrexone will do you any good, in my opinion. Maybe you would be b...

These problems are unheard of in Germany. If there is no obvious reason to be suspicious of the prescription, the pharmacy is ordered by law to fill the prescription. And the diagnosis is of no concern for the pharmacy. This is the job of the physician. I am not aware of even one story or report whe...

I've tried Clonidine like everything else that could work in theory. It did not work for me. It is well known that Clonidine can help with sleeping disorders, especially when connected to ADHD. However it seems that in most cases the hypnotic properties don't last very long and drugs like Clonidine ...

He should investigate if Lyrica is maybe triggering some RLS symptoms. In my own experiments it turned out that Lyrica can trigger some horrible symptoms.

Other secenarios: as others have suggested he still might be augmenting or he simply needs a higher dose of Methadone.

With the way Propofol works, I would agree that it is unlikely that it will cause / trigger RLS symptoms. Have there been any other drugs involved in the procedure? The pronounced symptoms could have been a random spike in symptoms or simply happened because you did not move because you were sedated...

wantok wrote:Does alerting go away with time ever?

I went away after maybe 2 years on classic opioids like Morphine & Oxycodone but I still have big big trouble sleeping at night.

Methadone is also more problematic than classic opioids.

For example additional Carbamazepine helped me sleep for 4 years. So far this have been the best years with my disorder and since it stopped working, I can't do much. Time to try it again? or is it too soon? I tried. It is not really helpful anymore. The Oxcarbamazepin I take as a replacement is si...

Yes, Steve is right. Very important to start slow and go slow and especially with edibles, it can take up to 4 hours for the full effect to manifest itself. When I started with Cannabis, 2,5 mg of THC consumed orally was already enough to make me super stoned for more than 12 hours. If you are an in...

Tramadol can be one of the most stimulating / alerting properties because it also has additional serotonergic effects. Tramadol is not a classic, pure opioid and it is chemically related to a very stimulating antidepressant (Venlafaxine). In fact there are even people who get addicted to Tramadol be...

New update: #1 The Pedanios 20 / 1 seems to work best for sleeping purposes while the Bedrocan offers better pain relief. However when I skip my cannabis meds for a day because I feel like I don't need them, the next time I use cannabis it often feels like that cannabis is worsening my symptoms in t...

I take 30 mg Oxycodone per day ... however I also take around 90 to 120 mg Morphine and sometimes 4 mg Hydromorphone. I do have to combine different opioids because when I only take one, it is not enough, even when I raise a lot. Also opioids alone were never enough for me. I have to take additional...

I thought that the dosage used for pain was more than RLS dosages usually? I take almost 200 mg Morphine (or 100 mg Oxycodone) daily. The individual doses depends on the individual needs of the patient. But is it true that most RLS patients need lower opioid doses than the average chronic pain pati...

I have been working with primary care doc and he seemed freaked by the amount of oxycodone that was "equivalent" to 6mg. of methadone when I suggested the change, and it made me nervous. (But then the methadone has kind of turned me into a nut case.) Nervous as well because I see the oxyc...

There is also this https://en.wikipedia.org/wiki/Monoamine_oxidase This enzyme deals with dopamine "not longer needed". If you read those two articles I linked it should answer all your question. I thought about an easier way to answer you questions but since you asked so many and don't se...

"Unused" dopamine goes back into the cells it was released from.

Here, this explains more about the situation: https://en.wikipedia.org/wiki/Dopamine_transporter