NADH helpsdopamine production

[Robin-Whittle]

In March, in the "Tyrosine experiment" thread, Sherry wrote of
her success with NADH and tyrosine. I will discuss NADH here in
a new thread. This is arguably a pharmaceutical approach, but
perhaps NADH or similar compounds are normally found in food,
so it could be thought of as a nutrient.

There is an article about NADH and RLS:

http://www.fitnessforoneandall.com/diff ... sc/rls.htm

It is not very authoritative, for instance the author thinks that
Mirapex (pramipexole) provides what is needed to create
dopamine. But Mirapex is a dopamine agonist - it behaves like
dopamine in that it trigger some of the dopamine receptors.

NADH (AKA Co-enzyme 1 or beta nicotinamide adenine
dinucleotide) is thought, by some, to help in the synthesis of
dopamine. For instance the article 9247090 at PubMed:

http://www.ncbi.nlm.nih.gov/entrez/

indicates this. Also:

http://www.custommedicine.com.au/brain-function/

which states that NADH helps produce tetra-hydrobiopterine
(AKA H4biopterine, H4BP), which helps tyrosine hydroxylase.
(Tyrosine hydroxylase converts tyrosine to L-DOPA which is
then converted into dopamine, which RLS sufferers are clearly
short of.)

Confirmation of this can be found at:

http://www.pharmacorama.com/en/Sections ... ines_3.php

NADH and NAD are part of the Krebs (citric acid) cycle:

http://en.wikipedia.org/wiki/Citric_acid_cycle

Some research in the 1990s indicated that NADH helped with
dopamine synthesis in ways which helped people suffering from
Parkinson's disease and depression:

http://www.wizardsgate.com/parkinso.htm
http://www.google.com/search?q=%22Birkm ... stitute%22

There are a number of papers I want to read by JG Birkmayer
(George Birkmayer).

Search http://www.ncbi.nlm.nih.gov/entrez/ for:

"Birkmayer JG"[Author]

Also, a recent interview:

http://www.immunesupport.com/library/sh ... /CFIDS_FM/

A widely copied article by James South is:

http://smart-drugs.net/JamesSouth-NADH.htm

This also discusses NADH's relationship with vitamin B3.

NADH is available commercially:

http://www.enadh.com/ http://www.nadh.com/

It is apparently patented by George Birkmayer. In some
countries no prescription may be required. I haven't yet found
a source in Australia - I think it is not allowed.

It makes sense to me that taking either NADH or tyrosine will
help produce more dopamine and so potentially reduce or
eliminate RLS. Taking both would probably be better. I think
the effects of tyrosine are limited to a few hours, but maybe
NADH lasts longer than this in the body.

Does anyone have any experience with NADH?


- Robin (rw@firstpr.com.au)