jumpyowl wrote:I remember reading about the interaction of dopamine agonist and opioid. To refresh everyone's memory: In one experiment, the patient was given earlier an opioid antagonist, then later was treated with a dopamine agonist. As expected, the opioid antagonist did not block the efficacy of the dopaminergic treatment. However, the preadministration of a dopamine antagonist did block the beneficial effect of the narcotic drug (opioid).
This is strange and I feel we should take this into account when using the two types of drugs together as I am doing (MX and HC). However, I do not know enough about the mechanism of action of these receptor sites. I would welcome any suggestion, while I am studying this aspect of the RLS scene.
This is good information for me as Ms. B prescribed me Hydrocodone yesterday. They are 5mg/500mg tablets. She prescribed 2 eevry four to six hours as needed. So I took two tablets last night and they made me VERY ill. Spent time throwing up about 30 minutes after taking them. They also made it very difficult to sleep. Do you or did you have trouble getting to sleep while taking it? It made me very drowsy (drug drowsy) but still was very hard to get to sleep and woke up from vivid dreams all night. I don't think it's a good drug for me. I hope the Ultram works better. I did take the Mirapex first, last night, so maybe that has something to do with it. I plan to take the H first tonight..only one tablet and .5mgs Mirapex second. How long do you wait between taking the two?