One aunt and two cousins is enough to say it's in the family. It would strengthen a diagnosis, but ultimately does not affect how you're treated.
One of the most important things for you to consider is your AD and AP meds. (By the way, depression and WED often co-occur, so your situation is not unusual.) What I wonder is how your WED/RLS started. Was it sudden? Did you have it for years in an intermittent or very mild form, or did it pop up out of the blue? Or both - did it suddenly get super-worse? And did that change coincide with the change in AD to Zoloft, or with the introduction of Risperdal? Wellbutrin is one of the few ADs thought to be WED-friendly. Not everyone with WED has a bad effect from ADs but those who do seem to have a strong effect. You may be one of them. Both Zoloft and Risperdal are listed among the drugs that worsen WED, and you're taking both of them. If you're susceptible, that might be why it all flared up.
If the worsening coincided with one of those drug changes, to confirm it, you could stop the one or two drugs that you think might be causing the WED and see if it goes away. This is not ideal, since it leaves you untreated for depression meantime; and if you were to do it, you would have to do it in partnership with your psychiatrist. In any event, you have two choices if you decide the WED might be caused by one or more of your other meds. One is to treat the WED that is caused by the AD/AP meds with more meds. Two is to try to find AD/AP meds that do not worsen your WED. I recommend wherever possible to reduce your total drug load, and to avoid adding drugs if at all possible. Explore the other anti-depressants and anti-psychotics with your psychiatrist.
One thing that is hard for a lot of us to understand, and I'd like to save you learning the hard way if I can, is that you don't often get answers from your doctors about this disease, instead
you sort of have to point
them to the answers. I am actually impressed with your GP, who must know some of this since she has immediately put you on iron supplements, without putting you on DAs first. Maybe she knows the terrible trouble WED patients have been having with DAs and doesn't want to start you down that route.
But your psychiatrist - and any average Joe Doctor, even a specialist - is not likely to know any of this. You will probably have to point him toward the information, so it would be best if you prepared yourself. Start with the WED Foundation's brochure for healthcare providers (don't worry, it's really good for patients too):
WED/RLS Medical Bulletin: A Publication for Healthcare Providers. I recommend you have a printout of the brochure handy during your appointment, and offer him a copy. ("Would you like this? I've read parts of it. ... yadayada") Read it before you go, and highlight the parts that you think are especially relevant to you - as Polar Bear said, he won't have time to read the whole thing. eg. the paragraph on page 5 that reads
It is also helpful to examine other substances the person is
taking that may exacerbate his or her WED/RLS symptoms,
including both over-the-counter and prescription
medications (Table 6). Any dopamine-blocking agents can
aggravate WED/RLS, and these include almost all the
neuroleptics plus many anti-nausea agents. Many antidepressants may aggravate WED/RLS symptoms.
However, bupropion (Wellbutrin), a dopamine-active
antidepressant, may prove to be the most preferred
antidepressant.39,40 Among over-the-counter medications,
centrally active (mostly sedating) antihistamines may be the
greatest culprits. These are often found in over-the-counter
medications to treat allergies or promote sleep.
Also Table 6 that lists the meds that can aggravate WED.
If you end up treating the WED because adjusting your other meds is not feasible, your psychiatrist or GP will (after looking it up) recommend one of the approved meds, which are the dopamine agonists (pramipexole/Mirapex, ropinirole/Requip, and the Neupro/rotigotine patch) and one anti-convulsant patch (Horizant/gabapentin encarbil). The DAs (dopamine agonists) should not be taken until your ferritin is over 100, and that tidbit of information is not likely to be in their manuals or online databases. (It is in various medical-journal papers; some of them can be found by following the second link below my name at the bottom of all of my posts.) So if he/she suggests you go on a DA, tell him/her that you heard that's a bad idea as long as your ferritin is lower than 100. You can point them to the Buchfuhrer paper if they want a reference for that.
Just so you know, there are lots of options if the approved meds don't work out: there are more anti-convulstants (Neurontin/gabapentin, Lyrica/pregabalin) and a whole slew of opioids. There are also tricks and techniques and life-style changes. Viewsaskew has mentioned some of them. I'm another person who takes vitamin D - I take 3000-4000 IU daily - you might ask to have your D levels tested next time you're being sent for blood work, because apparently a lot of North Americans are deficient. Another lifestyle change to consider is eliminating coffee - for some people, this means all caffeine, but for me, it seems my WED is not affected by chocolate or tea.
No matter what you do with your other meds ( - even if you find out it is them causing the WED, and switch them to something else that does not cause WED) I advise you to keep taking the 2 x 325 ferrous sulfate per day. After 3 months on the two pills, get another ferritin test. If it's over 100, you can consider stopping, but I suspect you will then begin to feel the WED again. As soon as you do, get your ferritin checked again. If you're like the rest of us, it will be below 100 again, and it will keep dropping unless you're supplementing. No one has figured out what dysfunction causes this inability of our bodies to retain iron, but there's a direct correlation between low ferritin and strong WED/RLS symptoms, this has been shown in the medical literature (also in second link after my name), not just my opinion. Personally, I notice within 2 days - only two days! - if I stop taking my iron. I've been taking same as you 2x325 ferrous sulfate daily for 3-4 years now. That seems to be the amount I need to take to keep my ferritin above 100. And it never gets above 130, even though I've been taking it for over 3 years.
Trazadone is a good choice. It can enhance sleep as well as have an AD effect. You are not likely to notice its benefit as long as you are being aggravated by the worsened WED, though. It is not enough by itself to get the WED under control.
Doctors don't always know the best course of treatment right off the bat for any disease, and WED is particularly hard for them because the treatment differs for every one of us plus it's so poorly publicized in medical school. Hopefully your WED problem is going to be solved by adjusting the other meds. That won't make your life perfect, but it should make it a lot easier to live. Your poor GP obviously became a GP and not a psychiatrist for a reason; whoever says "just stop doing it" fails to grasp the essential nature of the problem.