When you know make a google search for Melatonin and Restless Legs Syndrome, you find a webpage that states:
7. Don't try melatonin
Though restless legs syndrome can disrupt sleep, this common over-the-counter sleep supplement won't help, according to a 2004 Canadian study.
The naturally occurring hormone melatonin regulates your body's internal clock, or circadian rhythms. Its levels typically increase at night and taper off toward daybreak.
Melatonin also inhibits the secretion of dopamine, which makes it bad news for restless legs syndrome patients. It might increase RLS symptoms in the evening and night, according to researchers at Sacre-Coeur Hospital in Montreal.
In addition I have to say that Melatonin derivatives like the prescription drug Agomelatine (trade name: Valdoxan) can worsen RLS symptoms, too.
I think the problem for me was that my RLS baseline symptoms just got worse and worse and while those drugs were initially helpful, I stopped tolerating them after about 6 months, just like it happened with caffeine.
The use of medical Marijuana has now significantly improved my baseline symptoms and few days ago I started giving Melatonin 2nd attempt in the hope that medical Marijuana will now protect me against the worsening of my RLS symptoms.
This worked really well in the past 4 days. It made falling asleep so much easier and faster.
The question only is: how long will it be effective and what will happen: will it just stop working or will it start worsening my RLS symptoms again?
I don't expect it to work longer than 2-3 months, indeed I am actually surprised with it working in the past 4 days.
All I would want is to survive on Melatonin until I get the iron infusions. There is no telling when this will happen but there is no way it will happen sooner than by the end of February.
So getting some control back with Melatonin alone would be great.
For sure this will put medical Marijuana to the test since I know that without it, I will suffer significant additional symptoms when I use drugs like Melatonin or consuming even small amounts of caffeine.
And sure okay, I am also hoping it might work a little bit longer, maybe even long-term but this is really unlikely to happen. Most likely it will just stop working some day or cause additional symptoms. And then I have to stop and might be able to restart it a few months later.
Since Melatonin was so effective in the past, I have tried it a few times over the years again but not since I started using medical Marijuana.
To me this also proves again that medical Marijuana does not only help with insomnia & sleep quality but that medical Marijuana can have genuine positive effects on all the major RLS symptoms.
If medical Marijuana can make long-term therapy with Melatonin viable, that could help all of us who have major issues with our circadian rhythm in general outside of the RLS context.