2022 STUDY supports the existence of links between systemic inflammation and RLS

[CalmLegsJL]

Here is another study that investigated the possible link between Restless Legs Syndrome and inflammation.

Their research lead to the conclusion that there is a link.

Side note. Someone on this board suggested that I start to include all the data instead of just the conclusion.

I'm going to continue posting just the conclusions to keep it short and sweet. If you're interested in reading the entire article, you can click on the link at the end of this post.

CHRONIC INFLAMMATION MARKERS AND CYTOKINE-SPECIFIC AUTOANTIBODIES IN DANISH BLOOD DONORS WITH RESTLESS LEGS SYNDROME
Joseph Dowsett, Maria Didriksen, Jakob Hjorth von Stemann, Margit Hørup Larsen, Lise Wegner Thørner, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Morten Bagge Hansen, Jesper Eugen-Olsen, Karina Banasik & Sisse Rye Ostrowski

Discussion

We examined whether historical plasma measurements of the chronic inflammation markers hsCRP and suPAR, as well as five c-aAb, were associated with RLS in otherwise healthy Danish blood donors. We report associations between elevated levels of CRP and RLS, and between suPAR and RLS with frequent symptoms (though dependent on smoking and BMI), and high IFN-α autoantibody levels in individuals with RLS. These intriguing findings support the notion that links between RLS and systemic inflammation exist.

Conclusion

Using Danish blood donors, our study indicates that a high concentration of CRP is associated with RLS, while an elevated plasma suPAR level, linked to lifestyle factors, increases the probability of experiencing frequent RLS symptoms. We additionally report that a high titer of IFN-α autoantibodies was associated with RLS. Our results support the existence of links between systemic inflammation and RLS, though further RLS studies on CRP, suPAR and c-aAb in larger cohorts and in RLS patients with higher frequency and severity are warranted to confirm our findings and further reveal the hitherto under-explored links between RLS and inflammation.

https://www.nature.com/articles/s41598-022-05658-1