Scientists identify inflammation as the primary cause of RLS

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Scientists identify inflammation as the primary cause of RLS

Postby davew » Sat Jun 11, 2011 12:05 pm

This is very exciting news for all RLS sufferers! The paper they have written is under review and should be published soon.

The paper is titled "Restless Legs Syndrome: Theoretical Roles of Inflammatory and Immune Mechanisms."

The paper was written by a team of 3 scientists.

One of its members, Dr. Arthur Walters, is a true RLS pioneer. He organized the first medical advisory board for the Restless Legs Syndrome foundation (RLSF), a nationwide patient based support group organization.

You can find more info about this upcoming paper here:

Polar Bear
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Postby Polar Bear » Sat Jun 11, 2011 1:59 pm

A very interesting paper, a lot of reading here.
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Postby Laurachrissy » Sat Jun 11, 2011 6:25 pm

Oh my goodness, now I just posted a question about Fibro and stuff that may be to blame. Thanks for this post!

Update: Inflammation must not be my problem....I have gotten it under control with prednisone, blood test to monitor esr/crp; low carb- no caffiene and I am still having same level of RLS (exacerbated 8 months ago-(Augmented?)
Last edited by Laurachrissy on Fri Oct 28, 2011 7:01 am, edited 2 times in total.
RLS sux

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re: inflammation as the primary cause of RLS

Postby davew » Sat Jun 11, 2011 6:58 pm


There are scientific studies listed on the following website for over 50 inflammation based diseases and conditions, including fibromyalgia.

The reason I listed them all is to show people that if inflammation is at the root of Cancer, Parkinson's, Crohn's, HIV, Obesity, ADHD, Depression - and so many more conditions ... then the odds are pretty good that RLS is also inflammation based.

Here's the entire list of inflammatory diseases/conditions:

Amyotrophic Lateral Sclerosis (ALS)
Aortic Valve Stenosis
Attention Deficit Hyperactivity Disorder (ADHD)
Celiac Disease
Chronic Fatigue Syndrome
Chronic Obstructive Pulmonary Disease
Chronic Sarcoidosis
Chronic Venous Disorder
Crohn's Disease
Cystic Fibrosis
Erectile Dysfunction (ED)
Heart Disease
Hodgkin Disease
Human Immunodeficiency Virus (HIV)
Huntington's disease
Irritable Bowel Syndrome
Kidney Disease / Renal Failure
Liver Disease
Lyme Disease
Multiple Sclerosis
Poliomyelitis (Polio)
Pulmonary Hypertension
Sjögren's Syndrome
Sleep Apnea
Small Intestinal Bacterial Overgrowth (SIBO)
Spinal Cord Conditions
Tourette's Syndrome

There haven't been studies done on all the above conditions to determine their relationship with RLS, but a great deal of them have been tested, and in every study, the occurrence of RLS is significantly higher than the general population (which is around 10%).

Another indicator that inflammation is at the core is the fact that through the hundreds of studies I read, there is a total interchange of these inflammatory diseases. Each disease has a higher rate of having other completely (seemingly) unrelated diseases.

For instance, in studies, people with Parkinson's would show a higher rate of Crohn's or people with MS would display a higher rate of arthritis, and so on.

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