Here you can share your experiences with substances that are ingested, inhaled, or otherwise consumed for the purpose of relieving RLS/WED, other than prescription medications. For example, herbal remedies, nutritional supplements, diet, kratom, and marijuana (for now) should be discussed here. Tell others of successes, failures, side effects, and any known research on these substances. [Posts on these subjects created prior to 2009 are in the Physical Treatments forum.]

Important: Posts and information in this section are based on personal experiences and recommendations; they should not be considered a substitute for the advice of a healthcare provider.
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Postby ViewsAskew » Sat Apr 05, 2014 4:18 am

Huh - wonder why they decided to follow this path.... ... treatment/

Upshot is that the NIH in the US funded three universities to study the role of manganese is RLS/WED. The study authors believe that if it works they could tailor treatment to each individual!
Ann - Take what you need, leave the rest

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Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.


Re: Manganese

Postby cornelia » Sat Apr 05, 2014 10:05 am

Gosh, this looks interesting and I hope it will be promising. It's good to read that dr Walters is included in the study. I especially like the mentioning of individualized treatment for RLS.


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Re: Manganese

Postby Rustsmith » Sat Apr 05, 2014 1:00 pm

This makes some sense to me. The chemistries of iron and Manganese are very similar to each other. Manganese isn't as abundant as iron, is a little bit larger and heavier and the reactions can be a bit stronger. However, with that said, it would be fascinating if they learn that the problem isn't iron but really manganese and that all the past findings on iron were really that the iron was just an indicator of manganese presence or absence.

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Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

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Re: Manganese

Postby badnights » Sun Apr 06, 2014 4:41 am

Ann, I think it says they decided to research it because they already knew that iron and manganese levels in the brain are interrelated, and that dopamine and manganese in the brain are interrelated. Knowing of these two relationships, plus the known relationships between WED and Fe, and WED and dopamine, suggested they should look for relationships between WED and Mn.

I don't know if that's what you meant, or if you wondered how they knew of the Fe-Mn and dopamine-Mn relationships, or what exactly those relationships are.
Beth - Wishing you a restful sleep tonight
I am a volunteer moderator. My posts are not medical advice. My posts do not reflect RLS Foundation opinion.

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Re: Manganese

Postby peanut1 » Sat Apr 12, 2014 4:50 pm

Thanks for the update. I've got some old manganeese on the shelf and I intend to finish it up now to see if it might work. Will post the results.

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