Peanut, how are you doing? I have not been on here for a while, but I am thrilled to hear you are doing better. I think you have found the closest thing to a cure that will be found for many years to come. I have read hundreds of articles and have concluded that a brain (not really body) iron deficiency is a major contributing factor to RLS. My body stores of iron are over 100 but based on articles I have read my RLS brain is incapable of storing iron. During the day, supposedly, our free floating unbound blood iron levels are good but at night human's blood iron levels drop. I picture the rest of the world making a withdrawal from their brain iron bank at night but we have a zero balance in that particular account. Anyways, whatever the case maybe, I know that myself and dozens of other have found relief with iron. For me I have to use ferrous bisglycinate, on an empty stomach, during an attack or about an hour before bed. Within an hour the RLS is gone for the night. If I don't have RLS, I don't take the iron. Science has learned so much in recent years about dosing with iron and they are rethinking that three time a day iron supplementation. They realized that with that very first iron pill of the day our bodies release a hormone called hepcidin. That hepcidin prevents the next iron pill from being absorbed from the GI tract. It takes at least 24 hours for that hepcidin to clear. So now scientists are thinking an every other day dose of iron might actually be better - at least for anemia
. I'm sure the same is true for RLS. Plus I truly believe that in order to work for RLS we have to take a form of iron that stands a chance of crossing the blood brain barrier. I think the bisglycinate is one of the forms capable of doing this. But if I take iron in the morning, even if it's the bisglycinate, it will do nothing for my night time RLS.