Would Augmentation Occur in Healthy Controls & Parkinson’s
Posted: Sat Jan 07, 2023 4:20 am
I’ve had some thoughts about augmentation and was hoping I could get some feedback. I’m trying to understand if only dopamine dysfunction could be the root cause and end-point for some people.
If I gave pramipaxole to my girlfriend who does not have RLS, would she eventually develop some form of augmentation? Or, does that mechanism only exist because we have RLS? Theoretically, she would develop the same up regulation and down regulation that causes RLS, right?
Similarly, do Parkinson’s patient’s experience augmentation? And, at similar rates? Please correct me if I am wrong, but a Parkinson’s patient would experiene RLS due to hypodopamanergic state? This is in contrast to other RLS which is largely theorized to be due to hyperdopaminergic state.
If I gave pramipaxole to my girlfriend who does not have RLS, would she eventually develop some form of augmentation? Or, does that mechanism only exist because we have RLS? Theoretically, she would develop the same up regulation and down regulation that causes RLS, right?
Similarly, do Parkinson’s patient’s experience augmentation? And, at similar rates? Please correct me if I am wrong, but a Parkinson’s patient would experiene RLS due to hypodopamanergic state? This is in contrast to other RLS which is largely theorized to be due to hyperdopaminergic state.