Recovery from augmentation-induced dopamine-system disruption?

Use this section to discuss your experiences with prescription drugs, iron injections, and other medical interventions that involve the introduction of a drug or medicine into the body. Discuss side effects, successes, failures, published research, information about drug trials, and information about new medications being developed.

Important: Posts and information in this section are based on personal experiences and recommendations; they should not be considered a substitute for the advice of a healthcare provider.
badnights
Moderator
Posts: 4834
Joined: Tue Mar 10, 2009 4:20 pm
Location: Northwest Territories, Canada

Recovery from augmentation-induced dopamine-system disruption?

Postby badnights » Tue Mar 27, 2018 11:28 pm

I've recently been considering this issue. A lot of us feel that we were permanently or semi-permanently damaged by augmentation on dopamine-type meds. At first the literature told us this was impossbile, but now medical researchers are starting to acknowledge that long-term damage might be caused by dopamine agonists.

It has always been an issue for me how to distinguish between permanent and long-term damage. I'm thinking about this now because of the slow but steady improvement in symptoms I've experienced since 2014. I've been sure - I still am sure - that the improvement was caused by the profound dietary changes I made in 2014. But maybe it was partly due to recovery of my dopamine system from whatever damage had been done to it. Perhaps, even, the diet gave my body the right nutrients to be able to recover.

Does anyone else have any thoughts on this? Has anyone else experienced improvement of symptoms?

For background, I was diagnosed and given ropinirole in 2008, and augmented within a week. I took increasing amounts for 3 months while I educated my doctor on augmentation. Then he switched me to pramipexole and we repeated the same thing over about 6 weeks. So, I was on DAs for a total of less than 5 months, not counting isolated times since then. I also spent a few months supplementing my other meds with a low dose of long-acting levo-carbidopa in 2012; I believe I augmented then, too, but it was mild because I stopped as soon as I noticed. Up until 2013, my dose of hydromorph contin had been increased every 6 or 12 months until I was on 18-21 mg daily. In 2014, 3 months after changing my diet, I started to lower my dose, a bit at a time, and I'm now at 6-10 mg daily. How much of this is diet, how much is dopamine-system recovery, how much is random unknowable reasons? I wish I knew.
Beth - Wishing you all restful sleep tonight
WED/RLS AUGMENTATION:
viewtopic.php?f=5&t=6532&p=61601#p61601
Discussion Board Moderator's posts don't reflect the RLS Foundation's opinion & are not medical advice

Return to “Prescription Medications”

Who is online

Users browsing this forum: No registered users and 3 guests