Good question! I am copying this from my own post to Ruby, as it is relevant to your question:
There are four primary approaches in medicating RLS:
1. Sedative/hypnotic medications benxodiazepines and non benzodiazepines
2. Dopamine agonists
3. Anticonvulsives
4. Analgesics (opioids)
I have read and seen many cases where the anti-Parkinsons and antiepileptic medications not only did not help but actually made things worse. And these were the very people who eventually received help from opioids. Just like in your case tashton.
I myself get relief with hydrocodone 2x (10mg/235 mg) once or twice a day and an occasional klonopin/clonazepam at night.
I have also used Neurontin and Topamax both anticonvulsants. They, especially the neurontin resulted in augmentation.
Flurazepam or Lorazepam from group #1 I also found helpful. (My wife likes Lorazepam but does not like Flurazepam.)
I hesitate to go too strong on this because I need more experience on my own.
As for myself, I would like to try Mirapex from #2, especially since anticonvulsants do not help consistently. I would not be surprised that if it did not help me. I would really like to take it for diagnostic purposes. This RLS is a thousand handled devil with one or at most two faces. It is also interactive depending on which medication you take.
The trouble with #2 and #3 is of course that they were developed for different neurogenic diseases. They are powerful drugs and RLS is clearly an off-label use (suggested on the basis of trial and error).
Tashton, how much lorazepam are you taking? Do you have pain with your RLS? I used it as a sleep aid off and on for twenty years from 0.5 mg once at night and up to 4-6 mg also once only at night. Usually took several days to wean off of it. The withdrawal effect was similar to perasthesia.
I do not take it any more since I was diagnosed with RLS/PLMD.