Dopamine question - even after all these years.

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sleepdancer2
Posts: 212
Joined: Sun Jun 29, 2014 7:46 am

Dopamine question - even after all these years.

Postby sleepdancer2 » Fri Jun 07, 2019 7:36 am

Was reading an article and discussing it with the person who shared it with me. It talked about how dopamine meds often have only a temporary effect and the propensity for augmentation. It mentioned how Magnesium, Vitamin D, and Iron are integral to processing dopamine. Makes common sense to me those things should be optimized before we put something in our bodies we can't process due to other deficiencies. Then questions ran across my mind that I realized I am totally uninformed about. What happens to unused dopamine in the brain? Is it harmful? How does it leave the body? Is augmentation caused by a buildup of unused dopamine, and if so, by what mechanisms does that happen? Just thinking about when there's too much iron in the body and wondering if it's a similar type issue with dopamine, where excesses get stored in a harmful manner. Figured I could find someone knowledgeable about this on here.
My Augmentation Sleep Video: https://www.youtube.com/watch?v=jE7WA_5c73c

QyX
Posts: 564
Joined: Wed Mar 13, 2013 12:53 pm
Location: Berlin / Germany

Re: Dopamine question - even after all these years.

Postby QyX » Fri Jun 07, 2019 11:31 pm

"Unused" dopamine goes back into the cells it was released from.

Here, this explains more about the situation: https://en.wikipedia.org/wiki/Dopamine_transporter

sleepdancer2
Posts: 212
Joined: Sun Jun 29, 2014 7:46 am

Re: Dopamine question - even after all these years.

Postby sleepdancer2 » Sat Jun 08, 2019 1:17 am

Thank you for the reference. Will spend some time digesting it.
My Augmentation Sleep Video: https://www.youtube.com/watch?v=jE7WA_5c73c

QyX
Posts: 564
Joined: Wed Mar 13, 2013 12:53 pm
Location: Berlin / Germany

Re: Dopamine question - even after all these years.

Postby QyX » Sat Jun 08, 2019 9:21 am

There is also this

https://en.wikipedia.org/wiki/Monoamine_oxidase

This enzyme deals with dopamine "not longer needed".

If you read those two articles I linked it should answer all your question.

I thought about an easier way to answer you questions but since you asked so many and don't seem to know many fundamentals of neurobiochemistry I thought it is best to post these links.

Also augmentation is not caused by a buildup of unused dopamine. There is not even such a thing as unused dopamine.

As far as I know it is not properly understood what causes augmentation.

Stainless
Posts: 142
Joined: Tue Dec 01, 2015 9:30 pm

Re: Dopamine question - even after all these years.

Postby Stainless » Sun Jun 16, 2019 5:03 pm

My doctor says she has had patients on DAs for decades for RLS. I have never met one. I know this forum caters to those seeking more help but is there anyone out there that knows one of these people successfully using DAs for decades.

I tried and supplements you mention by themselves and still do with lots of drugs but any relief for my severe RLS is in the noise. If you can get by with supplements even with some discomfort, more power to you and stay away from all the drugs. My brother only uses his hot tub after trying a DA.

Rustsmith
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Re: Dopamine question - even after all these years.

Postby Rustsmith » Mon Jun 17, 2019 2:43 am

There have been studies done by groups such as Johns Hopkins that compare the fraction of patients who augment on different DAs over extended periods of time. There are probably a few "outliers" that can go for decades, but the majority of patients will have augmented on most of the various products within the first ten years.
Steve

Augmentation Evaluation http://bb.rls.org/viewtopic.php?f=4&t=9005

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

badnights
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Re: Dopamine question - even after all these years.

Postby badnights » Fri Jun 28, 2019 6:09 am

There have been one or two people on here who took well over 10 years to augment. So perhaps there are others who have been taking DAs for well over 10 years who haven't augmented yet.
Beth - Wishing you a restful sleep tonight
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I am a volunteer moderator. My posts are not medical advice. My posts do not reflect RLS Foundation opinion.


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