Use this section to discuss your experiences with prescription drugs, iron injections, and other medical interventions that involve the introduction of a drug or medicine into the body. Discuss side effects, successes, failures, published research, information about drug trials, and information about new medications being developed.

Important: Posts and information in this section are based on personal experiences and recommendations; they should not be considered a substitute for the advice of a healthcare provider.
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Postby Camille4824 » Sun Jul 18, 2004 3:19 am

Hi everyone! Anyone ever take Carbidopa/Levodopa for RLS :?:

How did this work for you :?:

I don't see this drug being mentioned in any I am curious to know if any have been on this med??


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Location: Queensland, Australia

Re: Levodopa/Carbidopa Experiences

Postby sardsy75 » Sun Jul 18, 2004 10:36 am

Hi there :)

Levodopa/Carbidopa ... better known as Sinemet by most RLS'ers.

If you have read a bit about RLS and its treatments, you will have come across Sinemet.

Sinemet, being a Dopaminergic Drug, is usually one of the first lines of defense in treating RLS, however it has a short half-life, some nasty side-effects e.g. blood pressure problems, nausea, dizziness, etc; and has been recorded as causing major problems with rebound and augmentation.

How do I know? Been there ... done that!

I was "lucky" enough to be prescribed Sinemet in April this year and thankfully only on it for three weeks. Before I started on Sinemet, I was on Levodopa100mg/Benserazide25mg (Trade Name: Madopar) up to four times a day.

My initial Sinemet dosage was 1 x 250/25 tablet at night.

After one week, my RLS was so extreme my Neuro at the time, Dr S, simply doubled the dosage and so I was taking 1 x 250/25 tablet in the morning, and 1 x 250/25 tablet at night; and to make matters worse, he added 300mg Neurontin to the mix! (If you want to find out more about this, you can read more under my thread "Prescription Drug Side Effects" in the "New to RLS" Forum Topic).

300mg is the maximum recommended dosage of Levodopa for extreme RLS patients i.e. ME! And my dear Neuro (bless him!) had me on nearly double that!

In the end, I was having such bad augmentation from a major overdose of Levodopa, that it nearly sent me mad! However, my GP, Dr K was wise enough to sense that if his patient wanted OFF a drug, then she Ment It!

Well, that's been my experiences with Levodopa/Carbidopa. The Levodopa/Benserazide was not much better in the way of side effects and augmentation problems.

Some people are able to take Sinemet for years, without any major problems, others can't.

Below are some links to some websites which you might find useful.

RLS Treatment Information:

Fighting RLS with everything else:

The link below is to the RLS Foundation's 2004 Annual Report. It is a very informative read. ... lletin.pdf

Hope this has helped you out!

Take care of you

My philosophy is simply this: Life is too short to be diplomatic. Your friends should not care what you do, or say; and for those who are not your friends ... their loss!!!

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Postby Heronak » Mon Jul 19, 2004 3:22 pm

I got relief with Sinemet for about 3 weeks before experiencing augmentation which manifested as RLS symptoms during the day, and it stopped working at night. I've switched to Mirapex and am having success. See the Sinemet & Mirapex threads for details. Best,


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