Pharma Sticky

Use this section to discuss your experiences with prescription drugs, iron injections, and other medical interventions that involve the introduction of a drug or medicine into the body. Discuss side effects, successes, failures, published research, information about drug trials, and information about new medications being developed.

Important: Posts and information in this section are based on personal experiences and recommendations; they should not be considered a substitute for the advice of a healthcare provider.
ViewsAskew
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Re: Pharma Sticky

Postby ViewsAskew » Thu Jan 08, 2015 2:14 am

WOW - Go EU!

Basically, the EU has just approved the oxycodone/nalaxone combo for WED/RLS. Quoted from the following article, " Oxycodone/naloxone is the first opioid which has been granted a licence in the EU for the treatment of RLS.1 This new licence indication provides a viable treatment option for patients who cannot tolerate the existing available treatments or who are not able to gain the level of symptom relief required."2

http://www.businesswire.com/news/home/2 ... K3ni3u0uzk
Ann - Take what you need, leave the rest

Managing Your RLS

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

Rustsmith
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Re: Pharma Sticky

Postby Rustsmith » Sat May 09, 2015 11:31 am

This link is to an excellent writeup by Qyx that provides a comparison of equivalent doses of different opioid medications

http://bb.rls.org/viewtopic.php?f=4&t=9274&p=80064#p80064
Steve

Augmentation Evaluation http://bb.rls.org/viewtopic.php?f=4&t=9005

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

ViewsAskew
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Joined: Thu Oct 28, 2004 6:37 am
Location: Los Angeles

Re: Pharma Sticky

Postby ViewsAskew » Mon Jun 01, 2015 4:47 am

For those of you in the UK, you have access to a new drug for RLS/WED!

A quote: "Napp Pharmaceuticals Limited has announced that Targinact, a fixed combination of prolonged-release oxycodone/naloxone, has received approval for use in the UK. This follows the European Commission's positive decision in January 2015 to recommend Targinact as a second line symptomatic treatment for patients with severe to very severe idiopathic restless legs syndrome (RLS), after failure of dopaminergic therapy.1,Oxycodone/naloxone is the first opioid which has been granted a licence in the UK for the treatment of RLS.1 This new licence indication provides a viable treatment option for patients who cannot tolerate the existing available treatments or who are not able to gain the level of symptom relief required.2"

More: http://www.pharmiweb.com/pressreleases/ ... WupM0a0tE2#ixzz3bmab24y6
Ann - Take what you need, leave the rest



Managing Your RLS



Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

Polar Bear
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Location: N. Ireland

Re: Pharma Sticky

Postby Polar Bear » Mon Jun 01, 2015 1:27 pm

Ann - thank you for this. Great news :)
Betty
http://www.willis-ekbom.org/about-rls-wed/publications
Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation

ViewsAskew
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Posts: 15736
Joined: Thu Oct 28, 2004 6:37 am
Location: Los Angeles

Re: Pharma Sticky

Postby ViewsAskew » Wed Sep 14, 2016 4:52 am

Requip labeling has been updated. They now recommend a taper when stopping the drug, even when using for RLS. Not sure if this truly means at all dosages, but am guessing it does.

http://www.empr.com/news/requip-labelin ... le/522328/
Ann - Take what you need, leave the rest



Managing Your RLS



Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

leggo_my_legs
Posts: 343
Joined: Sun Oct 16, 2016 12:29 am

Re: Pharma Sticky

Postby leggo_my_legs » Wed Oct 19, 2016 6:36 am

I have to add to the phenergan nightmare. OMG. Was given that once for food poisoning and I was moving everything! Trunk movements bolting up in bed every few secs. It was horrendous. They called the MD in who said cooly, 'I think you're having a reaction to the medication." I was so far gone I said, "No, this just happens to me sometimes." Which it does NOT, i dont know why I said that. This was like 8 yrs ago, I still remember it like yesterday.

peanut1
Posts: 330
Joined: Sat Jun 04, 2011 8:06 am

Re: Pharma Sticky

Postby peanut1 » Wed Oct 17, 2018 10:54 pm

I am on hormone replacement therapy. I notice that if I take too much progesterone, the RLS goes mad.

badnights
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Re: Pharma Sticky

Postby badnights » Mon Aug 12, 2019 5:29 am

From Sleep Review, Jan 2018:
Dopamine Agonists May Cause Psychiatric Adverse Events, Even at Comparatively Low Doses

In 2004, neurologist Daniel Lee, MD, was one of the investigators who declared ropinirole a well-tolerated and effective treatment for restless legs syndrome (RLS), contributing to the US Food and Drug Administration’s (FDA) approval of ropinirole and ushering in an era of dopamine agonists as first-line treatment for RLS.

But now Lee—as well as other prominent sleep physicians—say clinicians and patients must be alerted to the psychiatric serious adverse events that may occur in patients taking dopamine agonists for RLS. Newer studies have found patients being diagnosed with psychiatric illnesses after taking dopamine agonists for RLS, including patients who had no prior psychiatric illness history.....

[Two petitions to the FDA have been filed asking for a black-box warning to be added to dopamine agonist meds, one in 2016 that focused more on Parkinson's patients and one in 2017 dealing with WED/RLS patients. The main psychiatric developments are impulse control disorders. ]

...In a 2010 study, published in the journal Sleep, Silber and co-researchers conducted a prospective case-control study on the frequency of impulse control disorders in patients taking dopaminergic agents for RLS. They found that, out of 100 participants, roughly 17% of the RLS treatment group had one or more of the impulse control disorders. ...

...Patients with RLS can suffer severely, Hankin says, citing examples of patients who inadvartantly bruise their own legs in attempts to get the restless sensations to alleviate. “The worst thing of all,” she says “is to add harm to patients who are already suffering.”

[Full story at http://www.sleepreviewmag.com/2018/01/r ... f=cl-title]
Beth - Wishing you a restful sleep tonight
Click for info on WED/RLS AUGMENTATION & IRON
I am a volunteer moderator. My posts are not medical advice. My posts do not reflect RLS Foundation opinion.


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