Posted: Thu Mar 06, 2008 7:23 am
I found this related to augmentation. It was published last year, Sleep Med. 2007 Oct 5
Background and purpose: Augmentation is a major problem with dopaminergic therapy for restless legs syndrome (RLS), and predictors of augmentation have not yet been identified. We aimed to analyze the relationship between baseline ferritin level and occurrence of augmentation in a retrospective analysis of a prospective double-blind trial of cabergoline versus levodopa on augmentation in RLS. Patients and methods: Patients who experienced augmentation were compared to patients who did not experience augmentation. Results: Augmentation symptoms causing premature discontinuation from the study or which were tolerated (n=36, ferritin: 85+59ng/ml) were associated with lower levels of serum ferritin compared to patients without augmentation (n=302, ferritin: 118+108ng/ml, p=0.0062). Conclusions: Ferritin as a marker of iron storage may play an important role in the pathophysiology of RLS and may prove to be a biomarker for the development of augmentation under dopaminergic therapy
Background and purpose: Augmentation is a major problem with dopaminergic therapy for restless legs syndrome (RLS), and predictors of augmentation have not yet been identified. We aimed to analyze the relationship between baseline ferritin level and occurrence of augmentation in a retrospective analysis of a prospective double-blind trial of cabergoline versus levodopa on augmentation in RLS. Patients and methods: Patients who experienced augmentation were compared to patients who did not experience augmentation. Results: Augmentation symptoms causing premature discontinuation from the study or which were tolerated (n=36, ferritin: 85+59ng/ml) were associated with lower levels of serum ferritin compared to patients without augmentation (n=302, ferritin: 118+108ng/ml, p=0.0062). Conclusions: Ferritin as a marker of iron storage may play an important role in the pathophysiology of RLS and may prove to be a biomarker for the development of augmentation under dopaminergic therapy