Thank you for telling us your experiences. You are right on the dot about profiles we are trying to do something similar. Take a look at the open forum on the topic "HELP WANTED started by Bcat. We do not have a form to fill out yet because I am trying to make it flexible and not too compartmentalized but is coming.
I discovered only a few months ago that I have paresthesia and since then I tried the following:
1. hydrocodone only; once a day one pill in the evening at 5mg/500 mg strength. It helped but I had to increase the dose to twice a day at 10mg/325 mg strength.
Since I had pain, and had a sleep test that showed that I have severe Leg Periodic Leg Movement during slow wave sleep (stage 4 and 5) the next medication logically had to be neurontin which is effective for nerve pain.
2, The doctor put me on Neurontin at 300 mg to be titrated up to 600 mg once in the evening. I took hydrocodone also. When I increased the dosage (doubled it actually) I started to have augmentation and the rebound effect. I also discovered by studying clinical trial protocols that one should never double the dose and take it at once. When spread to twice a day in the morning and the evening it worked better. Still shadow side effects and change in the type of pain made me wary.
3. I wanted to take a dopamine agonist, not Sinemet, which works differently and has bad side effects, but a true dopamine agonist of the non-ergotic type, Mirapex. Started with 0.25 mg one a day. The titrated it up to 0.25 mg twice a day. I still had to take hydrocodone with it at the 10 mg/325mg strength. I have not tried Requip yet which seems to be similar to Mirapex but probably similar enough to be compatible.
As an aside when I stopped neurontin cold and started Mirapex I had the weirdest vertigo for two days which petered out after that.
4. I wanted to exchange Hydrocodone to another pain medication, mainly to find out whether the paresthesia I have is a withdrawal syndrome of the codein derivative in Hydrocodone. So I started on Ultram 50 mg twice a day together with Mirapex at 0. 25 mg twice a day. I discontinued hydrocodone for the first time.
5.The result was a huge flare up of paresthesia. I had to resume taking hydrocodone again, albeit I started to decrease the dosage ot half of 10 mg/325 mg twice a day and I upped Mirapax to 0.5 mg twice a day.
I fall asleep in the evening readily but wake up after 4-5 hours of sleep. If I get up, I need sleep in the afternoon. I just did that. Woke up and got up at 3:30 AM. Took Mirapax and Ultram and went to work. I went to bed again at 11 am after taking an exotic sleeping draught that ensures stage 4 and 5 sleep. At 3 pm I woke up with a severe paresthesia. You see it was eleven hours after I took my first dose of MX and UL.
I took again Mirapax and Ultram but by mistake also took 0.5 mg Klonopin. I am keeping with me a Hydrocodone pill but will not take it until the evening if I can manage. And it will only be half a pill. If I keep busy I might make it.
Sorry I was going into detail but this is where I am now. It appears I need hydrocodone more than Ultram, but I want to see if I get off Hydrocodone and will be clear of it, whether the paresthesia will subside without Hydrocodone.
However in the evening it will be my third dose of Mirapax and Ultram.
How much Mirapex were you taking? Taking it earlier before the symptoms start is definitely a plus. We all found that out.
About the neurotransmitter you heard about, it would not be dopamine by any chance?
Perhaps you can give us a hand with the profiles by writing an outline. It could be for insulin, I would be mostly interested in the organization of it?
I am glad you decided to join us so to speak and I hope wou will keep posting.