Hi,
I came across the whole hepatoxicity issue months ago, and from what I could tell, it was pretty fairly rebuked through some case studies and whatnot.. Should be pretty easy to find on google, but I don't have links off hand.
In a lot of cases countries that banned it also took it off the ban list once the evidence was brought forth.. Personally I think its another case of irrational drug control..
If this stuff were truly that toxic all the natives that harvest it and consume it almost daily would be dropping like flies, I would think.. They get this stuff straight from the plant and in high concentrations too, so it can't be that.. There would be more than the few cited deaths around the world.. I'm pretty sure in all those cases other health issues were cited at the cause of the problem.
That being said there are plenty of things OTC that will kill you, i.e Tylenol.. So I don't understand why some people rationalize fear of one product vs another.. I am very cautious of what I take though and research thing thuroughly before trying anything out.. If anything people will probably continue to bring it up as a scare tactics because of Kava's reported narcotic like effects (take enough of it and you get a buzz or something) or they have ulterior corporate motives.
Case in point.. L-Trypophan.
http://www.ceri.com/trypto.htm
On June 15, 1993, the FDA Dietary Supplement Task Force published a report on the work it had been doing in the area of developing FDA policy around nutritional supplements. On page two, the report admits, “The Task Force considered various issues in its deliberations, including... what steps are necessary to ensure that the existence of dietary supplements on the market does not act as a disincentive for drug development.”
re: antidepressants. Up until my seizure I had been on an off various kinds since I was 21 and first saw my doctor. They have helped me at various points, but I find little use for them these days.. Most of them do aggravate my RLS, and also make it almost unbearable for my prostate when taken together with painkillers of any kind (that I know of).
I have had bad cases of urinary retention that weren't fun.. The only one I would go back to is Luvox, which interacted with my Tramadol of course, but also helped with some mild OCD symptoms of mine and I think did make me less anxious to a degree.. However it is listed as a drug that can effect methadone levels (potentiate) and I don't want to take that kind of risk with an accidental OD or something.