Trivastal or agomelatine?

k8samms · Post by **k8samms** » Mon Aug 24, 2009 7:34 am

Anyone here tried either of these two drugs for their RLS? (Both are available in Europe.) If so, what was your experience?

Post by **Polar Bear** » Mon Aug 24, 2009 8:10 am

I have never heard of either of these drugs.

Post by **ViewsAskew** » Mon Aug 24, 2009 10:03 am

k8samms, what you you hoping to find about these two drugs? Or, rather, what do you want them to do for you?

k8samms · Post by **k8samms** » Mon Aug 24, 2009 8:25 pm

One is a dopamine agonist (with some noradrenergic effect) and the other is a 5ht2c antagonist (which should also increase dopamine). From what I've read about them and heard from those who have taken them, they have a fairly benign side effect profile. Those who I know that have taken them have tried them for reasons other than RLS but what I'm hoping is that they can treat RLS with less side effects and perhaps less risk.

Neco · Post by **Neco** » Tue Aug 25, 2009 2:00 pm

If it's anything like 5HTP, there probably won't be much benefit, as I did try that for a while and noticed no improvement. Its good for mood stabilization, but that's about it.. Has wicked nausea if you take too much too, although can produce bursts of euphoria as well.

Don't really know much about 5htc2 however, but I'm wondering if they are similar in what they are supposed to accomplish.

k8samms · Post by **k8samms** » Wed Aug 26, 2009 5:59 am

5htp behaves like an agonist to increase serotonin. Agomelatine is an antagonist for a particular serotonin subtype receptor (among other things) and so works in the opposite way as 5htp. So while 5htp would probably make the condition worse, this might help.

I don't remember if I've typed this yet but I know of one person who has taken this and he said that it helped his RLS. I don't know how bad his RLS is though or whether this helped enough on its own that he didn't need any other medication.

I'm probably just reaching for the stars here but I'm hoping that this would work because it has so few side effects and no withdrawal syndrome. (I'm such a coward.)

bekull · Post by **bekull** » Wed Aug 26, 2009 5:33 pm

We are all reaching for the stars here

Neco · Post by **Neco** » Wed Aug 26, 2009 5:48 pm

Best thing to do is to try it yourself and then let everyone know of your experience.

Its unlikely anyone else is gonna try it anytime soon, as most of the regulars here are on mostly stable medication regimes.

But your research may be of benefit to those who read or pass thru looking for non-pharmaceutical solutions.

SquirmingSusan · Post by **SquirmingSusan** » Wed Aug 26, 2009 8:53 pm

So agomelatine is an antidepressant that works similarly to Stablon? I've heard great things about that drug, as far as treating depression and I've been tempted to try it. It works opposite of SSRIs and yet if as effective or more effective than SSRIs, but doesn't cause fatigue and emotional flattening. Stablon has to be taken twice a day and gets pretty pricy, and for me it would require going off the SSRI I'm taking in order to try it...

I wish the US would get on board with some of these newer antidepressants that are available in Europe. I'm already mail ordering my reboxetine from England, and it would be so much easier if it were available locally. Grrr.

k8samms · Post by **k8samms** » Thu Aug 27, 2009 6:58 am

Zach,

I may try them someday. It takes me a while to get up the courage though. I met with my doctor to treat RLS for the first time today. He wants me to take neurontin and get some blood tests. I was surprised. I expected him to say Mirapex and blood tests. I did mention those other drugs and he's going to do some research on them. Since he also has RLS he is interested in other treatments.

K

k8samms · Post by **k8samms** » Thu Aug 27, 2009 7:04 am

SquirmingSusan,

Agomelatine and Trivastal are both much different than Stablon/tianeptine although Trivastal is made by the same company (the French company Servier) as Stablon. For some reason (probably political and/or monetary) we don't get approval of French drugs in this country. Stablon is a medication that I am interested in trying as well though I've heard that it makes some people quite anxious - even though it's touted as being good for anxiety. I was looking online earlier to see if there was any info on Stablon and RLS but couldn't find any. But that doesn't necessarily mean it wouldn't be good for RLS. Since it works opposite to SSRIs, it may be helpful.

K

Neco · Post by **Neco** » Thu Aug 27, 2009 2:50 pm

Hopefully having a doctor that also has RLS is gonna help you out in finding the treatment you need, as I would think they would be a little more open to trying unpopular or unresearched methods.

k8samms · Post by **k8samms** » Sat Aug 29, 2009 8:26 am

I hope so. Guess I'll find out soon enough.