dgarmaise wrote:Well, I feel like I am between a rock and a hard place. My regimen of 5mg methadone and 0.125mg pramipexole (and 2mg clonazepam), all taken in the evening, is simply not doing it for me. It is usually, but not always, enough to control the legs at night. It is not enough to control them during the day if I try to lie down. And I am suffering from insomnia....
David, I don't have a suggestion, but a couple of points. First, many of us with more severe RLS feel or have felt as you do, this is a frustratingly difficult disease to treat. Keep at it, likely you will come up with a treatment plan you can live with, even though it won't be completely satisfactory. It may take many months of trying different things.
For reasons that are unclear, lots of us have inexplicable day to day variation of symptoms. I may have five days of fairly good control, then a terrible day or night. So if a treatment regimen is helping for many but not all days, don't give it up just because it is not consistently effective.
Insomnia unrelated to jumpy legs is part of more severe RLS.