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Gralise

Posted: Mon Jun 12, 2017 7:32 pm
by MariS
My Neuro is prescibing Gralise. Gabapentin works ok for me but does not completely control my RLS/PLMD. I've tried everything else but opiods and Horizant. Other meds all have severe side effects for me leading to visits to Urgent Care. Gralise will be the latest in a long line of trial and lots of error.

Does anyone find that Gralise works better than Gabapentin and is worth the very expensive price tag? I start it tonight using free samples from Neuro but the free samples are only good for a few weeks.

I see a new RLS specialist Neuro in August so I guess this at least will tell us if this works or not. Present Neuro is avoiding opiods, I'm now leaning that way. Spent this last Saturday yet again at Urgent Care due to severe Lyrica side effects and I'm really tired of RLS all day/night and very scary side effects.

I take iron and have ferritin levels checked every 6 mos. Have had sleep study done, etc etc. You name it, I've done it, ingested it, or am still ingesting it for RLS/PLMD and am very frustrated.

So, my latest question is: does Gralise work better than Gabapentin for some of you?

Re: Gralise

Posted: Mon Jun 12, 2017 8:31 pm
by stjohnh
Hmmm. Gralise is slow release gabapentin. Seems a bit odd that your doc would give you this rather than Horizant, seeing as that Horizant is FDA approved for RLS. Maybe your doc didn't have any Horizant samples. I haven't used it, but in general should work about the same as regular gabapentin. Might have better side effect profile at higher doses since it will give more consistent blood levels than regular gabapentin. Let us know how it works for you.

A search of the forum shows only MaggieM mentioning Gralise, so you probably won't get too many replies.

How about trying kratom?

Re: Gralise

Posted: Tue Jun 13, 2017 8:53 am
by badnights
Seems a bit odd that your doc would give you this rather than Horizant
Ditto. Can you ask him why? or would that make him get his back up....

I am having another angry moment, with no one to direct my anger against, except generally against doctors who are ignorant of RLS/WED. There are lots of different opioid meds, any one of which could work for you. I hope this new guy in August is not afraid to treat your agony.

Re: Gralise

Posted: Mon Jun 19, 2017 10:12 pm
by MariS
Gralise, extended gabapentin, doesn't seem to work any better for me than plain old gabapentin. Gralise = $265/month Gabapentin = $7.00/month.

Re: Gralise

Posted: Tue Jun 20, 2017 12:10 am
by Rustsmith
MariS, that was my exact experience when my doctor insisted that I try Horizant (including the price tag). Plain gabapentin worked just as well. He seemed surprised, but since he was on the team that conducted clinical trials on Horizant, it shouldn't have been that much of a surprise.