Published Research - General Sleep and RLS (WED)

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Rustsmith
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Re: Published Research - General Sleep and RLS (WED)

Post by Rustsmith »

I don't have access through my other resources yet, since it was only published on Friday. Even Google Scholar doesn't list it yet. Maybe in a week or two.
Steve

https://www.mayoclinicproceedings.org/a ... 0/fulltext
Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Post by ViewsAskew »

I knew they were working on some mouse models; will be interesting to see how close the symptoms appear to be to humans.
Ann - Take what you need, leave the rest

Managing Your RLS

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badnights
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Re: Published Research - General Sleep and RLS (WED)

Post by badnights »

The original article:http://onlinelibrary.wiley.com/doi/10.1002/mds.27133/epdf
The comment: I can't access it yet.
The reply to the comment: http://onlinelibrary.wiley.com/doi/10.1002/mds.27263/epdf

I'm not sure that these links will always work but I Was able to download pdfs of the original article and the reply.
Beth - Wishing you a restful sleep tonight
Click for info on WED/RLS AUGMENTATION & IRON
I am a volunteer moderator. My posts are not medical advice. My posts do not reflect RLS Foundation opinion.

jul2873
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Re: Published Research - General Sleep and RLS (WED)

Post by jul2873 »

Ann, I'm not sure how to post this article here. It's about a possible link between RLS and ADHD. https://www.healthcentral.com/article/i ... g-syndrome

Thanks,

Mary

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Post by ViewsAskew »

Thank you, Mary! The link is perfect.
Ann - Take what you need, leave the rest

Managing Your RLS

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Post by ViewsAskew »

badnights wrote:The original article:http://onlinelibrary.wiley.com/doi/10.1002/mds.27133/epdf
The comment: I can't access it yet.
The reply to the comment: http://onlinelibrary.wiley.com/doi/10.1002/mds.27263/epdf

I'm not sure that these links will always work but I Was able to download pdfs of the original article and the reply.


thanks, Beth!
Ann - Take what you need, leave the rest

Managing Your RLS

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Post by ViewsAskew »

More associations with heart disease - this time women are on the losing end.

https://www.msn.com/en-ph/health/medica ... srcref=rss
Ann - Take what you need, leave the rest

Managing Your RLS

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

Rustsmith
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Re: Published Research - General Sleep and RLS (WED)

Post by Rustsmith »

This paper by Dr Earley, et al. was published last March.
In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine
in Sleep Medicine. The abstract that is publicly available is pretty useless, but the paper has several very interesting statements.
1. When taking oral iron, the body releases hepcidin which inhibits further adsorption of iron from the GI tract for 24 hrs. Therefore, they recommend only taking one dose of oral iron each day since the rest will not be adsorbed.
2. Ferrous sulfate tablets require a very acidic environment in the stomach because the body oxidizes the ferrous to ferric (this requires a pH of about 2). It is then the ferric ion that is adsorbed to form transferritin. This is why it is necessary to take iron on an empty stomach along with Vitamin C or as ferrous gluconate. I should add (not in the paper) that drinking milk at the same time or taking something to reduce stomach acidity will also inhibit the ferrous to ferric transformation and therefore prevent adsorption.
3. They state
Although iron has known interactions with DA, acting as a cofactor for tyrosine hydroxylase, the rate-limiting enzyme in DA produc-
tion, this is unlikely the pathway by which it effects the DA system, because DA synthesis appears to be increased in RLS
. So, they really don't know how our low iron levels.
4. Although gabapentin and pregabalin are structurally similar to GABA, another neurotransmitter, they do not think that these two meds act on GABA receptors. Instead, it appears that they are involved with calcium ion transport through the nerve cell membrane.
5. Their conclusions state
There is increasing evidence from preclinical and clinical studies that links brain iron deficiency and impairments in glutamatergic and adenosinergic neurotransmission as pathogenetic mechanisms involved in RLS. This provides the impetus for alternative treatments to DA receptor agonists, which are associated with augmentation of RLS symptoms. These alternative new treatments could not only provide clinical relief when used as monotherapy, but also when associated with lower doses of dopaminergic compounds, which are less prone to augmentation
Steve

https://www.mayoclinicproceedings.org/a ... 0/fulltext
Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Post by ViewsAskew »

Thanks, Steve. Some very helpful and interesting tidbits there.
Ann - Take what you need, leave the rest

Managing Your RLS

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Polar Bear
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Re: Published Research - General Sleep and RLS (WED)

Post by Polar Bear »

Don't have time to go check - but I think Dr Earley is doing a Webinair in a few weeks on the matter of iron.
Betty
https://www.mayoclinicproceedings.org/a ... 0/fulltext
Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation

Rustsmith
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Re: Published Research - General Sleep and RLS (WED)

Post by Rustsmith »

Dr Earley's webinar is scheduled for January 25.
Steve

https://www.mayoclinicproceedings.org/a ... 0/fulltext
Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

Rustsmith
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Re: Published Research - General Sleep and RLS (WED)

Post by Rustsmith »

A paper was just published in the January edition of the Mayo Clinic Proceedings titled "The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome" by Drs Ondo, Buchfuhrer, Winkelman, Earley, Walters, Becker and Silber. Since it was just published, I haven't been able to find anything more than the title. But I will keep looking of the coming days.
Steve

https://www.mayoclinicproceedings.org/a ... 0/fulltext
Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

Polar Bear
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Re: Published Research - General Sleep and RLS (WED)

Post by Polar Bear »

Points 1 and 2 explain very well why it is necessary to take an iron supplement properly.
Betty
https://www.mayoclinicproceedings.org/a ... 0/fulltext
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badnights
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Re: Published Research - General Sleep and RLS (WED)

Post by badnights »

A paper was just published in the January edition of the Mayo Clinic Proceedings titled "The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome" by Drs Ondo, Buchfuhrer, Winkelman, Earley, Walters, Becker and Silber. Since it was just published, I haven't been able to find anything more than the title. But I will keep looking of the coming days.
This is great. We'll have something to refer our doctors to now.
Beth - Wishing you a restful sleep tonight
Click for info on WED/RLS AUGMENTATION & IRON
I am a volunteer moderator. My posts are not medical advice. My posts do not reflect RLS Foundation opinion.

Polar Bear
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Re: Published Research - General Sleep and RLS (WED)

Post by Polar Bear »

badnights - I'd also really like to see that - to have for my GP.
Betty
https://www.mayoclinicproceedings.org/a ... 0/fulltext
Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation

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