Published Research - General Sleep and RLS (WED)

For everything and anything else not covered in the other WED/RLS sections.
Sleuth
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Postby Sleuth » Sat Jan 02, 2010 6:09 pm

I have a lot of gastro problems. I have diverticulitus. I was just on cipro a couple of weeks ago. I don't recall it helping my RLS much.

I will mention this SIBO to my gastro doctor, though. I'll try anything.

Dale

ViewsAskew
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Postby ViewsAskew » Wed Jan 06, 2010 7:30 pm

Interesting research of some older adults with early stage dementia regarding RLS.
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doety
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Estrogen?

Postby doety » Thu Jan 07, 2010 6:15 pm

I haven't followed the whole thread; maybe this has been discussed. One study a few pages back indicated that pregnant women had higher levels of estrogen, and of course that's one time when RLS is really bad. Then comes menopause, where estrogen is depleted and RLS gets worse. Strange. Has estrogen ever been shown to help RLS?

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Re: Estrogen?

Postby ViewsAskew » Fri Jan 08, 2010 4:06 am

doety wrote:I haven't followed the whole thread; maybe this has been discussed. One study a few pages back indicated that pregnant women had higher levels of estrogen, and of course that's one time when RLS is really bad. Then comes menopause, where estrogen is depleted and RLS gets worse. Strange. Has estrogen ever been shown to help RLS?


Not that I know of...but something particular to women and probably to reproduction is likely involved simply because women have RLS 3:1 over men until menopause....then it's 1:1 in terms of occurrence.
Ann - Take what you need, leave the rest



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Neco
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Postby Neco » Fri Jan 08, 2010 3:12 pm

I always assumed most cases of pregnancy RLS had to do with depleted Iron since the baby uses the mothers blood as well?

Betty/WV
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Postby Betty/WV » Fri Jan 08, 2010 3:48 pm

Regarding RLS and sleep. I was looking up some information on Mirapex and one of the side effects is INSOMNIA. So even though Mirapex keeps my RLS at bay----I am only sleeping a couple hours at a time. I am right back where I started, almost, before I couldn't sleep because of the RLS, now I can't sleep because of the meds I take for the RLS. I guess its better than the misery of RLS but I need sleep. Sometimes I feel SOOOO confused. Like I'm losing my mind.

And I can't take Ambien, I took it one night and got up and roamed all over the house, and eating things that I didn't remember the next day. Scarey!! :shock: :x :cry:

BETTY/WV
Thanks to rls.org, I have learned so much about my condition. I have received encouragement from my friends here. This is a site I can come to when I am up most of the night, and I vent, and know those who read my messages understand

Polar Bear
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Postby Polar Bear » Fri Jan 08, 2010 10:12 pm

Yes, I knew that insomnia was a side effect of Mirapex and Ropinerole (which I am using) and also went through the wide awake nights, even if my legs were behaving themselves.

I then look Ambien which only gave me a couple of hours sleep. My regime actually was to fall asleep for a couple of hours which I could do naturally if my rls was well medicated, then when I woke up I took the Ambien and got another couple of hours.

This still wasn't enough sleep when I was in full time work and I spoke with the doc who then gave me Lunesta and I get about 4 hours out of it.

So on a good night, my pattern is: go to sleep naturally (fingers crossed) for about 2 hours, wake up, take my Lunesta and go to the computer for about an hour until it starts to work. Then hopefully get another maybe 4 hours sleep. Now that I am retired from full time work I am not under the pressure of a time factor.

On occasion, next day, I have read posts that I had forgotten I had posted, I sort of do remember as I read them. I have spent nights getting up and down, in and out, next day would have no idea how often I had been up, and even if I knew it was twice, I would not be able to say at what times, even tho I always look at the clock when I awaken.

And yes, I've also done the middle of the night toast thingy, the packet of choccy cookies, roaming. often the toast and the cookies together during any given nocturnal roaming. Maybe also cornflakes. I really had to take myself in hand and bought really good quality fruit, really juicy strawberries/ clemantines etc. and try and offset the carbs and calories.

What I don't do, is lie in bed and try to sleep when sleep is not there. I get up and use the pc, read, empty the dishwasher etc. etc. .... and eat fruit...... On a rough night its fruit and then the cookies :) :) I guess I am afraid if I just lie there that the rls symptoms will kick in (even tho I also take a ropinerole at around 3 am).

Sorry to ramble on here, just want to say, you are not alone. The misery of exhaustion and being unable to sleep is a nightmare. Or it would be a nightmare if you could get to sleep. lol. Sorry - bad joke.

However I still continue to take the sleeping pill. Can't imagine coping without it.

And yes, it is scarey that we can be so forgetful and/or confused when taking a drug to help us.
Betty
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Betty/WV
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Postby Betty/WV » Fri Jan 08, 2010 11:08 pm

Sounds like me Polar Bear. I eat also when I am prowling the house. No wonder I am overweight. But that one night I took the Ambien, I in my half concious state, ate half an ice cream cake. The next morning when I didn't see it in the freezer, I blamed my husband for eating it. Then when I found the fork with ice cream on it, it dawned on me that I had eaten it. Scared the wits out of me. What if I had went out of the house or got in the car etc. etc.

I think what I will do, is when I wake up in the middle of the night I will take a tramadol. And see if that helps me get a few more hours sleep.

I found your post interesting. Nice reading it. BETTY/WV
Thanks to rls.org, I have learned so much about my condition. I have received encouragement from my friends here. This is a site I can come to when I am up most of the night, and I vent, and know those who read my messages understand

doety
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consequences

Postby doety » Sat Jan 09, 2010 12:11 am

I've taken so many meds over the last 16 years, I can't remember what this was -- but I woke up one morning and smelled like chlorine. My bathing suit was wet in the bathroom -- obviously I had gone down to the condo pool and gotten in the hot tub. That's so scary!! There was also another incident where my boyfriend, who lived with me, mentioned something about the "night before." I didn't remember that we had had a "night before." You just wonder what the heck is in these medications -- if some of them can cause a gambling addiction, you don't know what else is in the mix.

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Study on Transferrin and Ferritin

Postby ViewsAskew » Mon Jan 25, 2010 7:51 pm

Study Link


I can't tell how new this is, but it links low ferritin in the CFS - cerebrospinal fluid - and high transferrin to folks with RLS. It also found no differences between non RLSers and RLSers in terms of blood ferritin. Huh.

I wonder if those of us with low blood ferritin are the outliers, based on this. I wonder how our symptoms differ?
Ann - Take what you need, leave the rest



Managing Your RLS



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Postby ViewsAskew » Wed Feb 24, 2010 7:27 am

Studycomparing sleep EEG profiles of RLS patients and depressed patients. From Journal of Neuropsychobiology.

Abstract below in case the link breaks:

Comparison of Sleep EEG Profiles of Patients Suffering from Restless Legs Syndrome, Restless Legs Syndrome and Depressive Symptoms, and Major Depressive Disorders
Serge Branda, Antreas Lehtinena, Martin Hatzingerb, Edith Holsboer-Trachslera

aDepression Research Unit, Psychiatric Hospital of the University of Basel, and bPsychiatric Outpatient Department, University Hospital Basel, Basel, Switzerland

Address of Corresponding Author

Neuropsychobiology 2010;61:41-48 (DOI: 10.1159/000262179)

goto top of page Key Words

* Depressive symptoms
* Major depressive disorders
* Restless legs syndrome
* Polysomnography
* Sleep disorders

goto top of page Abstract

Background: Depressive disorders and restless legs syndrome (RLS) demand particular attention because sleepiness, daytime fatigue and loss of interest are symptoms attributable to both depressive disorders and RLS. Moreover, a high comorbidity rate is observed. The aim of the present study was to compare polysomnographic data of patients suffering from RLS, RLS and depressive symptoms, and major depressive disorders (MDD).

Methods: Sleep EEG recordings of patients suffering from RLS (n = 25), RLS and depressive symptoms (n = 38), as well as MDD (n = 15) were compared. Results: Compared to patients with MDD, both groups with RLS had statistically decreased values of sleep continuity, including sleep efficiency, sleep onset latency and wakening after sleep onset. Patients with RLS or RLS and depressive symptoms had also decreased slow-wave sleep compared to patients with MDD.

Conclusions: Objective sleep assessment supports previous findings: RLS is a disorder seriously affecting sleep, even compared to MDD. Concomitant symptoms of depression do not seem to additionally deteriorate sleep, though they trigger differences in treatment.
Ann - Take what you need, leave the rest



Managing Your RLS



Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

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Postby ViewsAskew » Fri Mar 19, 2010 4:31 am

Huh - people undergoing chemo have about double the rate of RLS.

http://www.springerlink.com/content/c363754342g8q818/
Ann - Take what you need, leave the rest



Managing Your RLS



Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

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Postby ViewsAskew » Thu Apr 15, 2010 7:52 am

Holy cow...I sure wish I could read this study!

http://www.nature.com/nrgastro/journal/ ... 10.32.html

Nature Reviews Gastroenterology and Hepatology 7, 186 (April 2010) | doi:10.1038/nrgastro.2010.32

IBD: Crohn's disease and restless legs syndrome

Isobel Franks
Abstract

Restless legs syndrome (RLS) is associated with Crohn's disease according to the results of a new study. The authors of this study suggest that RLS could be an extraintestinal manifestation of Crohn's disease.
Ann - Take what you need, leave the rest



Managing Your RLS



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Neco
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Postby Neco » Thu Apr 15, 2010 3:27 pm

Forward link to Dr. B and see if he has access / can share thoughts?

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Postby ViewsAskew » Thu Apr 15, 2010 6:34 pm

Great thinking, Zach. Must be great minds think alike, lol, as I had the same thought (and did send an email).
Ann - Take what you need, leave the rest



Managing Your RLS



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