Published Research - General Sleep and RLS (WED)

For everything and anything else not covered in the other RLS/WED sections.
Rustsmith
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Re: Published Research - General Sleep and RLS (WED)

Postby Rustsmith » Sun Dec 10, 2017 10:46 pm

I don't have access through my other resources yet, since it was only published on Friday. Even Google Scholar doesn't list it yet. Maybe in a week or two.
Steve

Augmentation Evaluation http://bb.rls.org/viewtopic.php?f=4&t=9005

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Postby ViewsAskew » Mon Dec 11, 2017 12:33 am

I knew they were working on some mouse models; will be interesting to see how close the symptoms appear to be to humans.
Ann - Take what you need, leave the rest

Managing Your RLS

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badnights
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Re: Published Research - General Sleep and RLS (WED)

Postby badnights » Fri Dec 15, 2017 7:15 am

The original article:http://onlinelibrary.wiley.com/doi/10.1002/mds.27133/epdf
The comment: I can't access it yet.
The reply to the comment: http://onlinelibrary.wiley.com/doi/10.1002/mds.27263/epdf

I'm not sure that these links will always work but I Was able to download pdfs of the original article and the reply.
Beth - Wishing you all restful sleep tonight
WED/RLS AUGMENTATION:
viewtopic.php?f=5&t=6532&p=61601#p61601
Discussion Board Moderator's posts don't reflect the RLS Foundation's opinion & are not medical advice

jul2873
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Re: Published Research - General Sleep and RLS (WED)

Postby jul2873 » Sun Dec 17, 2017 2:27 pm

Ann, I'm not sure how to post this article here. It's about a possible link between RLS and ADHD. https://www.healthcentral.com/article/i ... g-syndrome

Thanks,

Mary

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Postby ViewsAskew » Mon Dec 18, 2017 3:39 am

Thank you, Mary! The link is perfect.
Ann - Take what you need, leave the rest



Managing Your RLS



Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Postby ViewsAskew » Mon Dec 18, 2017 3:39 am

badnights wrote:The original article:http://onlinelibrary.wiley.com/doi/10.1002/mds.27133/epdf
The comment: I can't access it yet.
The reply to the comment: http://onlinelibrary.wiley.com/doi/10.1002/mds.27263/epdf

I'm not sure that these links will always work but I Was able to download pdfs of the original article and the reply.


thanks, Beth!
Ann - Take what you need, leave the rest



Managing Your RLS



Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Postby ViewsAskew » Wed Dec 20, 2017 2:51 am

More associations with heart disease - this time women are on the losing end.

https://www.msn.com/en-ph/health/medica ... srcref=rss
Ann - Take what you need, leave the rest



Managing Your RLS



Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

Rustsmith
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Re: Published Research - General Sleep and RLS (WED)

Postby Rustsmith » Tue Jan 02, 2018 4:45 pm

This paper by Dr Earley, et al. was published last March.
In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine
in Sleep Medicine. The abstract that is publicly available is pretty useless, but the paper has several very interesting statements.
1. When taking oral iron, the body releases hepcidin which inhibits further adsorption of iron from the GI tract for 24 hrs. Therefore, they recommend only taking one dose of oral iron each day since the rest will not be adsorbed.
2. Ferrous sulfate tablets require a very acidic environment in the stomach because the body oxidizes the ferrous to ferric (this requires a pH of about 2). It is then the ferric ion that is adsorbed to form transferritin. This is why it is necessary to take iron on an empty stomach along with Vitamin C or as ferrous gluconate. I should add (not in the paper) that drinking milk at the same time or taking something to reduce stomach acidity will also inhibit the ferrous to ferric transformation and therefore prevent adsorption.
3. They state
Although iron has known interactions with DA, acting as a cofactor for tyrosine hydroxylase, the rate-limiting enzyme in DA produc-
tion, this is unlikely the pathway by which it effects the DA system, because DA synthesis appears to be increased in RLS
. So, they really don't know how our low iron levels.
4. Although gabapentin and pregabalin are structurally similar to GABA, another neurotransmitter, they do not think that these two meds act on GABA receptors. Instead, it appears that they are involved with calcium ion transport through the nerve cell membrane.
5. Their conclusions state
There is increasing evidence from preclinical and clinical studies that links brain iron deficiency and impairments in glutamatergic and adenosinergic neurotransmission as pathogenetic mechanisms involved in RLS. This provides the impetus for alternative treatments to DA receptor agonists, which are associated with augmentation of RLS symptoms. These alternative new treatments could not only provide clinical relief when used as monotherapy, but also when associated with lower doses of dopaminergic compounds, which are less prone to augmentation
Steve

Augmentation Evaluation http://bb.rls.org/viewtopic.php?f=4&t=9005

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

ViewsAskew
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Re: Published Research - General Sleep and RLS (WED)

Postby ViewsAskew » Wed Jan 03, 2018 8:33 am

Thanks, Steve. Some very helpful and interesting tidbits there.
Ann - Take what you need, leave the rest



Managing Your RLS



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Polar Bear
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Re: Published Research - General Sleep and RLS (WED)

Postby Polar Bear » Wed Jan 03, 2018 10:58 pm

Don't have time to go check - but I think Dr Earley is doing a Webinair in a few weeks on the matter of iron.
Betty
http://www.willis-ekbom.org/about-rls-wed/publications
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Rustsmith
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Re: Published Research - General Sleep and RLS (WED)

Postby Rustsmith » Wed Jan 03, 2018 11:26 pm

Dr Earley's webinar is scheduled for January 25.
Steve

Augmentation Evaluation http://bb.rls.org/viewtopic.php?f=4&t=9005

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

Rustsmith
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Re: Published Research - General Sleep and RLS (WED)

Postby Rustsmith » Fri Jan 05, 2018 5:28 pm

A paper was just published in the January edition of the Mayo Clinic Proceedings titled "The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome" by Drs Ondo, Buchfuhrer, Winkelman, Earley, Walters, Becker and Silber. Since it was just published, I haven't been able to find anything more than the title. But I will keep looking of the coming days.
Steve

Augmentation Evaluation http://bb.rls.org/viewtopic.php?f=4&t=9005

Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation, and are not medical advice.

Polar Bear
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Re: Published Research - General Sleep and RLS (WED)

Postby Polar Bear » Fri Jan 05, 2018 9:32 pm

Points 1 and 2 explain very well why it is necessary to take an iron supplement properly.
Betty
http://www.willis-ekbom.org/about-rls-wed/publications
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badnights
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Re: Published Research - General Sleep and RLS (WED)

Postby badnights » Sun Jan 07, 2018 6:18 pm

A paper was just published in the January edition of the Mayo Clinic Proceedings titled "The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome" by Drs Ondo, Buchfuhrer, Winkelman, Earley, Walters, Becker and Silber. Since it was just published, I haven't been able to find anything more than the title. But I will keep looking of the coming days.
This is great. We'll have something to refer our doctors to now.
Beth - Wishing you all restful sleep tonight
WED/RLS AUGMENTATION:
viewtopic.php?f=5&t=6532&p=61601#p61601
Discussion Board Moderator's posts don't reflect the RLS Foundation's opinion & are not medical advice

Polar Bear
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Re: Published Research - General Sleep and RLS (WED)

Postby Polar Bear » Mon Jan 08, 2018 5:51 pm

badnights - I'd also really like to see that - to have for my GP.
Betty
http://www.willis-ekbom.org/about-rls-wed/publications
Opinions presented by Discussion Board Moderators are personal in nature and do not, in any way, represent the opinion of the RLS Foundation


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