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Re: Published Research - General Sleep and RLS (WED)

Posted: Sun Dec 10, 2017 10:46 pm
by Rustsmith
I don't have access through my other resources yet, since it was only published on Friday. Even Google Scholar doesn't list it yet. Maybe in a week or two.

Re: Published Research - General Sleep and RLS (WED)

Posted: Mon Dec 11, 2017 12:33 am
by ViewsAskew
I knew they were working on some mouse models; will be interesting to see how close the symptoms appear to be to humans.

Re: Published Research - General Sleep and RLS (WED)

Posted: Fri Dec 15, 2017 7:15 am
by badnights
The original article:http://onlinelibrary.wiley.com/doi/10.1002/mds.27133/epdf
The comment: I can't access it yet.
The reply to the comment: http://onlinelibrary.wiley.com/doi/10.1002/mds.27263/epdf

I'm not sure that these links will always work but I Was able to download pdfs of the original article and the reply.

Re: Published Research - General Sleep and RLS (WED)

Posted: Sun Dec 17, 2017 2:27 pm
by jul2873
Ann, I'm not sure how to post this article here. It's about a possible link between RLS and ADHD. https://www.healthcentral.com/article/i ... g-syndrome

Thanks,

Mary

Re: Published Research - General Sleep and RLS (WED)

Posted: Mon Dec 18, 2017 3:39 am
by ViewsAskew
Thank you, Mary! The link is perfect.

Re: Published Research - General Sleep and RLS (WED)

Posted: Mon Dec 18, 2017 3:39 am
by ViewsAskew
badnights wrote:The original article:http://onlinelibrary.wiley.com/doi/10.1002/mds.27133/epdf
The comment: I can't access it yet.
The reply to the comment: http://onlinelibrary.wiley.com/doi/10.1002/mds.27263/epdf

I'm not sure that these links will always work but I Was able to download pdfs of the original article and the reply.


thanks, Beth!

Re: Published Research - General Sleep and RLS (WED)

Posted: Wed Dec 20, 2017 2:51 am
by ViewsAskew
More associations with heart disease - this time women are on the losing end.

https://www.msn.com/en-ph/health/medica ... srcref=rss

Re: Published Research - General Sleep and RLS (WED)

Posted: Tue Jan 02, 2018 4:45 pm
by Rustsmith
This paper by Dr Earley, et al. was published last March.
In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine
in Sleep Medicine. The abstract that is publicly available is pretty useless, but the paper has several very interesting statements.
1. When taking oral iron, the body releases hepcidin which inhibits further adsorption of iron from the GI tract for 24 hrs. Therefore, they recommend only taking one dose of oral iron each day since the rest will not be adsorbed.
2. Ferrous sulfate tablets require a very acidic environment in the stomach because the body oxidizes the ferrous to ferric (this requires a pH of about 2). It is then the ferric ion that is adsorbed to form transferritin. This is why it is necessary to take iron on an empty stomach along with Vitamin C or as ferrous gluconate. I should add (not in the paper) that drinking milk at the same time or taking something to reduce stomach acidity will also inhibit the ferrous to ferric transformation and therefore prevent adsorption.
3. They state
Although iron has known interactions with DA, acting as a cofactor for tyrosine hydroxylase, the rate-limiting enzyme in DA produc-
tion, this is unlikely the pathway by which it effects the DA system, because DA synthesis appears to be increased in RLS
. So, they really don't know how our low iron levels.
4. Although gabapentin and pregabalin are structurally similar to GABA, another neurotransmitter, they do not think that these two meds act on GABA receptors. Instead, it appears that they are involved with calcium ion transport through the nerve cell membrane.
5. Their conclusions state
There is increasing evidence from preclinical and clinical studies that links brain iron deficiency and impairments in glutamatergic and adenosinergic neurotransmission as pathogenetic mechanisms involved in RLS. This provides the impetus for alternative treatments to DA receptor agonists, which are associated with augmentation of RLS symptoms. These alternative new treatments could not only provide clinical relief when used as monotherapy, but also when associated with lower doses of dopaminergic compounds, which are less prone to augmentation

Re: Published Research - General Sleep and RLS (WED)

Posted: Wed Jan 03, 2018 8:33 am
by ViewsAskew
Thanks, Steve. Some very helpful and interesting tidbits there.

Re: Published Research - General Sleep and RLS (WED)

Posted: Wed Jan 03, 2018 10:58 pm
by Polar Bear
Don't have time to go check - but I think Dr Earley is doing a Webinair in a few weeks on the matter of iron.

Re: Published Research - General Sleep and RLS (WED)

Posted: Wed Jan 03, 2018 11:26 pm
by Rustsmith
Dr Earley's webinar is scheduled for January 25.

Re: Published Research - General Sleep and RLS (WED)

Posted: Fri Jan 05, 2018 5:28 pm
by Rustsmith
A paper was just published in the January edition of the Mayo Clinic Proceedings titled "The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome" by Drs Ondo, Buchfuhrer, Winkelman, Earley, Walters, Becker and Silber. Since it was just published, I haven't been able to find anything more than the title. But I will keep looking of the coming days.

Re: Published Research - General Sleep and RLS (WED)

Posted: Fri Jan 05, 2018 9:32 pm
by Polar Bear
Points 1 and 2 explain very well why it is necessary to take an iron supplement properly.

Re: Published Research - General Sleep and RLS (WED)

Posted: Sun Jan 07, 2018 6:18 pm
by badnights
A paper was just published in the January edition of the Mayo Clinic Proceedings titled "The Appropriate Use of Opioids in the Treatment of Refractory Restless Legs Syndrome" by Drs Ondo, Buchfuhrer, Winkelman, Earley, Walters, Becker and Silber. Since it was just published, I haven't been able to find anything more than the title. But I will keep looking of the coming days.
This is great. We'll have something to refer our doctors to now.

Re: Published Research - General Sleep and RLS (WED)

Posted: Mon Jan 08, 2018 5:51 pm
by Polar Bear
badnights - I'd also really like to see that - to have for my GP.