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Important Links

Posted: Tue Jan 20, 2009 12:09 am
by ViewsAskew
This is a sticky topic that holds links to threads/topics of enduring importance, that people want to have easily available, that are viewed or referred to frequently. Instead of making each such thread/topic a sticky, we are placing links to them inside this one sticky. That way, we won't have so many stickies that you can't see the new posts.

This topic is locked and editable by moderators only because we want it to contain only links and not posts about links :). So if you would like to see something added here, please pm one of the moderators.

These should take you to posts that already exist. Some are updated frequently, some are not.

Posted: Tue Jan 20, 2009 12:12 am
by ViewsAskew
Click on any of these below. The research ones are updated periodically and may contain many pages of posts. To see the newest posts, go to the last page!

Clinical research and Trials

Published Research: General RLS Topics

RLS In the News

Posted: Tue Jan 20, 2009 12:16 am
by ViewsAskew
ADD and ADHD and RLS posts:


Posted: Tue Jan 20, 2009 12:18 am
by ViewsAskew
Ferritin Posts

viewtopic.php?f=4&t=8058 and in particluar: viewtopic.php?f=4&t=8058#p62957



added 2013:
Three papers that deal with ferritin and augmentation

Key excerpts from papers that deal with ferritin and augmentation

Buchfuhrer's 2012 paper, a good review of treatment, including comments on ferritin and augmentation:

Posted: Tue Jan 20, 2009 12:19 am
by ViewsAskew

Posted: Tue Jan 20, 2009 12:22 am
by ViewsAskew

Posted: Tue Jan 20, 2009 12:23 am
by ViewsAskew
Foods that bother RLS


Posted: Tue Jan 20, 2009 12:24 am
by ViewsAskew
Exercise and how it affects RLS


Posted: Tue Jan 20, 2009 12:24 am
by ViewsAskew

Posted: Tue Jan 20, 2009 12:30 am
by ViewsAskew
Finding a Good Doctor


Favorite Doctors(click on it to add yours)

Nationally renowned RLS/WED doctors(link added 2012)

Note to mods - I got through page 5 in this section.

Posted: Sat Mar 07, 2009 11:00 am
by ViewsAskew
The RLS Foundation website

Brochures and bulletins from the RLS Foundation: (these are PDF documents and require Adobe Reader to open; most computers have it but if you don't, you can download it for free from ). Note some of these still refer to RLS, the old name. They will all be updated over time to refer to WED, the new name.

Brochure about WED/RLS called Restless Legs Syndrome: Causes, Diagnosis and Treatment

WED Medical Bulletin for Healthcare Providers (2014 version) Aimed at healthcare providers, written by physicians, this document is very useful for patients who want to understand the disease. It has an algorithm that helps doctors make appropriate treatment decisions

WED/RLS Mimics

A Quick Guide to Living with WED/RLS (formerly the RLS Fact Sheet)

Coping Methods for WED/RLS

Medications for WED/RLS

WED/RLS Triggers

Augmentation in RLS/WED

Understanding WED/RLS and Iron

Activity, Exercise & WED/RLS

Depression and WED/RLS

Depression and RLS/WED (Healthcare Provider Series) Special Considerations in Treating Depression when the patient has Restless Legs Syndrome (RLS)

Pain & WED/RLS

Children and WED/RLS

Children and RLS/WED (Healthcare Provider Series) Restless Legs Syndrome and Periodic Limb Movement Disorder in Children and Adolescents: A Guide for Healthcare Providers (for healthcare providers)

WED/RLS in Cognitively Impaired and Older Adults

Surgery and RLS/WED (Healthcare Provider Series) Special Considerations for the Surgical Team when the patient has Restless Legs Syndrome

End-Stage Renal Disease and WED/RLS

Pregnancy and RLS/WED (Healthcare Provider Series) Vital Considerations in Treating a Pregnant Woman who has Restless Legs Syndrome

RLS/WED Patient Sleep Diary

WED/RLS Patient Symptom Diary

Clinical Trials: What to Know Before You Go

Scientific Bulletin (an example of what goes to the doctors who join the RLS Foundation at the heathcare provider level)

Other useful documents and websites:

Mayo Clinic algorithm for RLS/WED treatment

The website for the southern California support group of the RLS Foundation, maintained by Dr. M. Buchfuhrer, who will answer questions about your particular problems with RLS and provides an archive of previous questions and his answers.

[url=http:/]Jill Gunzel's website[/url] for non-pharmaceutical aids and for attitude

Good books about RLS/WED:

  • A book for physicians who have to treat RLS that is also very informative for patients:
    Hening, Buchfuhrer and Lee, 2013. Clinical Management of Restless Legs Syndrome, second edition
    (aka the little blue book)

  • A book for physicians or patients:
    Chokroverty, 2010. 100 Questions and Answers About Restless Legs Syndrome.

  • A book for patients that physicians could also learn from:
    Buchfuhrer, Hening, and Kushida, 2007. Restless Legs Syndrome; Coping with Your Sleepless Nights.

  • A book for lay people about RLS. This is my favorite to give people when I want them to understand the impact RLS has on one's quality of life: Yoakum, 2006. Restless Legs Syndrome: Relief and Hope for Sleepless Victims of a Hidden Epidemic.

  • A collection of technical papers by medical researchers: Hening, Allen, Chokroverty and Earley, 2009. Restless Legs Syndrome. Not for the layman, so you might have to look up some terms, or read things a few times before they make sense. But it's a pretty cool compilation of recent research.

If you would like to add something to the list, or if you find a broken link, please let us know!

edited by Ann 2012
Beth Apr 2014

Re: Important Links - Augmentation & Iron

Posted: Mon Jun 11, 2012 3:21 am
by badnights
Here are some research papers and book and website extracts that deal with augmentation, the link between ferritin (iron) and augmentation, and general diagnosis and treatment of WED/RLS:

NEW in 2018: The International RLS Study Group consensus guidelines on iron treatment for WED/RLS including iron infusions (IV iron treatments)
2018 IRRLS guidelines on iron in RLS-WED.pdf
(1.3 MiB) Downloaded 191 times

2016 editorial: Restless legs syndrome (Willis-Ekbom disease): An urgent need for better treatments - Advises against using dopamine agonists to treat augmentation in WED/RLS patients. From Sleep Medicine journal.
2106 WED need for new treatments -editorial.pdf
(126.47 KiB) Downloaded 240 times

The RLS Foundation's handouts on Augmentation
1. Go to the RLS Foundation website, click Member Portal at the top, click Publications in the drop-down list, and scroll down to Advanced Information. Download "What is Augmentation?"
2. Become a member, log in, click Member Portal at the top, click Publications in the drop-down list, and and scroll down to Advanced Information. Download "Augmentation: A quick Guide" and "Augmentation FAQ"
3. For real ammunition, scroll farther to Information for Healthcare Providers and download the 2017 RLS Medical Bulletin.

If you are not a member, go to and click Join or Renew - the red box at top right.
If you are broke and the small membership fee, which goes to support research as well as creation of these documents, is too much, you can email the Foundation about getting a scholarship (free) membership: or (507) 287-6465. It's worth it, to access these and other Foundation publications.

Buchfuhrer's 2012 paper: an excellent review of WED/RLS treatment, including lower recommended maximum daily doses for dopamine agents (0.25 mg for pramipexole, 1.0 mg for ropinirole), a cautionary note about impulse control disorder, treatment of augmentation, benefits of opioids, use of IV iron, combination and rotation of medications, and a recommendation to keep ferritin over 75 ng/ml: Citation: Buchfuhrer, Mark J., Strategies for the Treatment of Restless Legs Syndrome; Neurotherapeutics (2012) 9:776-790

**NEW** A magazine-style summary of Buchfuhrer's views (see above), from a 2015 issue of in Sleep Review Magazine:
The International RLS Study Group's 2015 white paper on augmentation prevention and treatment, with recommendations to keep ferritin over 50 or 75 ng/ml and transferrin saturation above 20%, and use of opioids in severe cases:
Extract from Clinical Management of Restless Legs Syndrome, 2nd edition, Treating Augmentation section, by Lee, H.B., Buchfuhrer, M.J., Allen, R. and Hening, W.A., 2013 (Professional Communications Inc., USA), p.181-183; treating augmentation and the use of potent opioids:
(464.2 KiB) Downloaded 444 times
This book also has the new recommended maximum daily doses of 0.25 mg for pramipexole on p.161-2 & p. 242, and 1.0 mg for ropinirole on p.164 & p. 242. This mulit-authored book would be a good choice to show your doctor.

From the Johns Hopkins Center for RLS website, a good description of the role of iron in RLS/WED; recommends raising ferritin to over 100 & trying iron infusions:
Johns Hopkins Center for Restless Legs Syndrome.pdf
(68.92 KiB) Downloaded 565 times

This research paper shows that low ferritin is associated with greater RLS/WED symptom severity and increased risk of augmentation:
This report from the International RLS Study Group recommends that serum ferritin be at least 75 ng/ml:
This research paper shows that augmentation due to dopamine medications is very common:
Allen+ 2011 _Augmentation is COMMMON.pdf
(1.98 MiB) Downloaded 504 times

This research note emphasizes that the incidence of augmentation in people being treated with dopamine agents increases over time:
The 2009 paper by Frauscher and others is the one that confirmed the association between low ferritin and greater chance of augmentation on dopamine agonists. A recommendation to get your ferritin levels to over 100 ng/mL can be found in the Johns Hopkins link above.

Edited for readability -Beth Apr 2014
Edited to add Augmentation extract -Beth Jan 2015
Edited to add IRLSSG 2015 white paper & note about free Foundation augmentation brochure -Beth Oct 2015
Edited to update links & improve readability -Beth June 2016
Edited to add 2016 editorial & to accommodate new website -Beth Mar 2017
Edited to add Sleep Review Magazine & extra info for other papers - Beth Sep 2017
Edited to add 2018 Iron Guidelines - Beth Oct 2018