My original post here is fairly old. At this time I do not believe that it's got anything to do with serotonine, and you are correct that we should look towards iron as the reason. My current hypothesis is this: We tend to produce nitrogen oxyde under high intensity workouts (anaerobic exercise levels). Nitrogen oxyde will be metabolized to a number of harmful substances (called "nitrosative stress"), including peroxynitrite which is toxic and affects iron regulatory proteins, and it takes the body a long time to "clean up" those unwanted substances.fuz_mind wrote:my idea of exercise and RLS is very simplistic. overdoing (depending on the state of your body) it causes depletion of iron --> triggers symptoms
certainly not as sophisticated as the above discussion which I'm enjoying (and trying to follow)
It's a shot in the dark, but probably better than serotonin Of course people with high nitrosative stress tend to have low neurotransmitter production, possibly due to the iron connection, so serotonin levels may be lowered as side effect.