Foundation webinar on Iron and Hypoxia
Posted: Sat Oct 15, 2016 1:29 pm
Yesterday the Foundation presented their webinar on iron and hypoxia. If you missed it, Foundation members can view it on the Foundation website.
I was expecting a rather low tech presentation, was I ever surprised! The information about current research that was presented was at a level that I sometimes found difficult to follow. But the overall concept presented made a lot of sense to me.
The presentation was given by two doctors at Penn State Univ. One is researching iron transport across the blood brain barrier and the other is looking at oxygen transport mechanisms in the body.
The biggest surprise is that they did not find a correlation between ferritin levels and RLS vs controls, but did find correlations with elevated hemaglobin and transferritin in the blood. They were quick to point out that they are not proposing any changes for the treatment of RLS and measurement of ferritin, yet. They are still recommending IV iron as a mode of treatment for RLS and ferritin as a measure for when this may be necessary.
The best summary of their message is that there seems to be something different with the messaging proteins of RLS patients that is telling the entire body that there is a hypoxia (low oxygen) condition. This results in a number of different things that have been reported in the literature of late. Although the oxygen levels are "normal" or maybe a little bit low for us, the error in the signaling is causing things such as increased blood flow to the femoral arteries in the legs and reduced iron transport across the blood brain barrier. The blood flow in the legs is greater in RLS patients than controls under normal conditions and when they create hypoxic conditions by having subjects breathe air with lower oxygen levels, our blood flow does not increase where flow for the controls increases to our "normal" levels.
As for the iron transport into the brain, they said that the body gives first priority for iron to hemaglobin production for oxygen transport. This is logical since neither the brain or the body can survive without oxygen. Iron transport to the brain only occurs when the oxygen transport need is satisfied. But with the improper signalling proteins, RLS brains get the needed iron because the body thinks it needs more oxygen.
They are still looking at the oxygen messaging protein(s) to figure out what is wrong with our systems.
When asked about iron supplements, they said that the human body really isn't set up for adsorbing the iron salts used for oral supplements. Heme iron from red meat works better, but has its limits. They said that the stomach upset caused by taking iron salts is due to bacteria in the gut that are much better at adsorbing iron. These bacteria go crazy when they see the iron salt, steal it from our system and the increased bacteria activity causes the stomach upset problems.
One question about hypoxia resulted in a couple of interesting facts. They reported that past research has shown higher incidence of RLS at higher elevations than at sea level. They also made it quite clear that the level of hypoxia that they are talking about for RLS patients is only slightly higher than for controls. This means that RLS patients are no where near the hypoxia conditions necessary for altitude sickness.
Finally, I don't want anyone to get the wrong message from this. They are not saying that we are hypoxic. Their message is that the messaging protein is causing our bodies to act like we are and that this is the reason why we have low iron in the brain and maybe even why our legs are the first to act up.
I was expecting a rather low tech presentation, was I ever surprised! The information about current research that was presented was at a level that I sometimes found difficult to follow. But the overall concept presented made a lot of sense to me.
The presentation was given by two doctors at Penn State Univ. One is researching iron transport across the blood brain barrier and the other is looking at oxygen transport mechanisms in the body.
The biggest surprise is that they did not find a correlation between ferritin levels and RLS vs controls, but did find correlations with elevated hemaglobin and transferritin in the blood. They were quick to point out that they are not proposing any changes for the treatment of RLS and measurement of ferritin, yet. They are still recommending IV iron as a mode of treatment for RLS and ferritin as a measure for when this may be necessary.
The best summary of their message is that there seems to be something different with the messaging proteins of RLS patients that is telling the entire body that there is a hypoxia (low oxygen) condition. This results in a number of different things that have been reported in the literature of late. Although the oxygen levels are "normal" or maybe a little bit low for us, the error in the signaling is causing things such as increased blood flow to the femoral arteries in the legs and reduced iron transport across the blood brain barrier. The blood flow in the legs is greater in RLS patients than controls under normal conditions and when they create hypoxic conditions by having subjects breathe air with lower oxygen levels, our blood flow does not increase where flow for the controls increases to our "normal" levels.
As for the iron transport into the brain, they said that the body gives first priority for iron to hemaglobin production for oxygen transport. This is logical since neither the brain or the body can survive without oxygen. Iron transport to the brain only occurs when the oxygen transport need is satisfied. But with the improper signalling proteins, RLS brains get the needed iron because the body thinks it needs more oxygen.
They are still looking at the oxygen messaging protein(s) to figure out what is wrong with our systems.
When asked about iron supplements, they said that the human body really isn't set up for adsorbing the iron salts used for oral supplements. Heme iron from red meat works better, but has its limits. They said that the stomach upset caused by taking iron salts is due to bacteria in the gut that are much better at adsorbing iron. These bacteria go crazy when they see the iron salt, steal it from our system and the increased bacteria activity causes the stomach upset problems.
One question about hypoxia resulted in a couple of interesting facts. They reported that past research has shown higher incidence of RLS at higher elevations than at sea level. They also made it quite clear that the level of hypoxia that they are talking about for RLS patients is only slightly higher than for controls. This means that RLS patients are no where near the hypoxia conditions necessary for altitude sickness.
Finally, I don't want anyone to get the wrong message from this. They are not saying that we are hypoxic. Their message is that the messaging protein is causing our bodies to act like we are and that this is the reason why we have low iron in the brain and maybe even why our legs are the first to act up.