Holland, hope you got another good night's sleep.
I have been re-reading the paper because we are in the middle of a snowstorm today. There are 2 sentences on page 4 that may explain why dropping your dose back has helped. These say
Under basal conditions, adenosine tonically activates predominantly A1R, which inhibits glutamate release. A2AR is activated with higher concentrations of adenosine, which would normally occur upon strong glutamatergic input. Activation of A2AR negatively modulates A1R signaling in the heteromers and promotes the opposite, glutamate release.
Since hyperarousal is due to a hyperglutamatergic state, I read that to say that increasing adenosine triggers A1R and lowers glutamate. But too much adeonsine triggers A2AR, which releases glutamate and therefore returns the hyperarousal state. If that is correct, there will be a sweet spot with dosing and ENT1 agonist. You need enough to reduce dopamine and glutamate levels, but not so much that it triggers A2AR and returns the hyperglutamate condition.