Search found 288 matches

by Frunobulax
Sat Jun 27, 2020 3:43 pm
Forum: Non-prescription Medicines, Supplements, Diet
Topic: Another year of relief (Low-oxalate diet)
Replies: 83
Views: 21096

Re: Another year of relief

No scientific papers or even speculation anywhere, no practical mechanism to link uric acid and oxalates. Oxalates are very well studied in the area of kidney stones, and less so in autism. There is this: https://pubmed.ncbi.nlm.nih.gov/19779706/ , https://www.sciencedirect.com/science/article/abs/...
by Frunobulax
Fri Jun 26, 2020 7:34 am
Forum: Non-prescription Medicines, Supplements, Diet
Topic: Another year of relief (Low-oxalate diet)
Replies: 83
Views: 21096

Re: Another year of relief

Please stick to this as most people don't try because they claim diet doesn't seem to impact them, or they don't see any quick improvements and give up. The essentials for dumping are citric acid, best from high dose Garcinia Cambogia, calcium citrate, magnesium other than chelate, and potassium ch...
by Frunobulax
Sun Jun 21, 2020 12:57 pm
Forum: Non-prescription Medicines, Supplements, Diet
Topic: Is it worth scrapping ever tiny bit of caffiene?
Replies: 14
Views: 611

Re: Is it worth scrapping ever tiny bit of caffiene?

Fascinating. I've been a lifelong tea drinker. But so is my father, who doesn't have RLS. RLS is hereditary in my fathers side though, my little brother doesn't drink tea but has RLS. If there should be two classes of main RLS causes (as sketched in http://bb.rls.org/viewtopic.php?f=5&t=10791 ), the...
by Frunobulax
Wed Jun 17, 2020 3:28 am
Forum: General Topics: RLS
Topic: Location of RLS Symptoms Changing
Replies: 19
Views: 407

Re: Location of RLS Symptoms Changing

And, we tend to have a bias for "natural" when that really doesn't mean anything. Arsenic is natural, for example. There are so many ways to approach this - we all just have to choose what we think is best, taking in account what matters most to us - and hoping our cognitive biases do not get in th...
by Frunobulax
Wed Jun 17, 2020 3:13 am
Forum: General Topics: RLS
Topic: Location of RLS Symptoms Changing
Replies: 19
Views: 407

Re: Location of RLS Symptoms Changing

In the end, it is all a trade off. Are you willing to sacrifice relief now for the hope of a cure later on? I’m only 33 and I’m willing to shave off some extra years later so that I can wake up refreshed and run around with my son. But, everyone’s situation is different. Well, we have no choice but...
by Frunobulax
Mon Jun 15, 2020 9:19 am
Forum: General Topics: RLS
Topic: Location of RLS Symptoms Changing
Replies: 19
Views: 407

Re: Location of RLS Symptoms Changing

Several of us augmented and it never returned to baseline. The docs usually try to say it is progression...but I think some of us are a bit skeptical. My baseline was very severe PLMS and very minor RLS. After augmentation, it was 24/7 RLS and severe PLMS. After treatment for augmentation, it was a...
by Frunobulax
Mon Jun 15, 2020 9:14 am
Forum: General Topics: RLS
Topic: Location of RLS Symptoms Changing
Replies: 19
Views: 407

Re: Location of RLS Symptoms Changing

Both legs at the start. Arms after starting with Gabapentin. Whole body when I was augmenting. Did gabapentin cause augmentation for you? No, I augmented on Pramipexole. Gabapentin was a fairly outlandish experiment of controlling my severe symptoms after coming off dopamine agonists. (Talk about o...
by Frunobulax
Sun Jun 14, 2020 1:30 pm
Forum: General Topics: RLS
Topic: Location of RLS Symptoms Changing
Replies: 19
Views: 407

Re: Location of RLS Symptoms Changing

Polar Bear wrote:
Thu Jun 04, 2020 6:14 pm
My RLS started in my legs, 90% in my right leg. 35 years sgo.
Then travelled to my arms.
Moving to my arms was nothing to do with augmentation as it was way before I started taking medication.
Both legs at the start. Arms after starting with Gabapentin. Whole body when I was augmenting.
by Frunobulax
Sun Jun 07, 2020 6:37 am
Forum: General Topics: RLS
Topic: The Relationship Between Inflammation and RLS
Replies: 19
Views: 467

Re: The Relationship Between Inflammation and RLS

I had not known that there was such a wide gap between the idea of science and its actual, imperfect application. I'm not sure what to do. It seems clear now that I really had no business proposing any kind of theory and that I have made a fool of myself. I guess that's why it takes so long to earn...
by Frunobulax
Sat Jun 06, 2020 5:43 am
Forum: General Topics: RLS
Topic: The Relationship Between Inflammation and RLS
Replies: 19
Views: 467

Re: The Relationship Between Inflammation and RLS

Like others, I have not had a chance to dig through all of the references provided in the original post by inflammatory_rls. However, when I wrote the missing post, I did get a full copy of the first reference to review. This paper is an example of why it is often important to be able to read the f...
by Frunobulax
Fri Jun 05, 2020 5:41 pm
Forum: General Topics: RLS
Topic: The Relationship Between Inflammation and RLS
Replies: 19
Views: 467

Re: The Relationship Between Inflammation and RLS

Reactive oxygen species (ROS), the main marker of systemic inflammation, It's misleading to say that ROS are "the main marker" of systemic inflammation. Although ROS are involved in the immune response, they are not routinely measured to detect inflammation. True. I should have been more specific: ...
by Frunobulax
Fri Jun 05, 2020 5:38 pm
Forum: Non-prescription Medicines, Supplements, Diet
Topic: Treating Central Nervous System Inflammation
Replies: 18
Views: 513

Re: Treating Central Nervous System Inflammation

What are your scientific or medical qualifications other than being avid readers? I'm a mathematician by trade. Driven by RLS and ME/CFS and little help from doctors, I started to dig deep into medical research about 6 years ago. Right now I'm even writing a book about nutrition, inflammation and a...
by Frunobulax
Thu Jun 04, 2020 6:13 pm
Forum: Non-prescription Medicines, Supplements, Diet
Topic: Treating Central Nervous System Inflammation
Replies: 18
Views: 513

Re: Treating Central Nervous System Inflammation

A year or two ago, I actually did start taking a multivitamin with Vitamins D, K, B6, B12, folate, and other compounds. As you note, I had read elsewhere online that these compounds may help in the "short term." I took the multivitamin for a couple weeks, but didn't notice any difference. Multivita...
by Frunobulax
Thu Jun 04, 2020 10:29 am
Forum: Non-prescription Medicines, Supplements, Diet
Topic: Treating Central Nervous System Inflammation
Replies: 18
Views: 513

Re: Treating Central Nervous System Inflammation

More than just eager to resolve my symptoms, I am borderline desperate.[...] So I have high hopes for this anti-inflammation approach. I fully agree that it would be more scientific to change only one variable at a time, but I just don't think I have the mental stamina to wait that long. A word of ...
by Frunobulax
Thu Jun 04, 2020 10:23 am
Forum: Non-prescription Medicines, Supplements, Diet
Topic: Treating Central Nervous System Inflammation
Replies: 18
Views: 513

Re: Treating Central Nervous System Inflammation

A reply to a small portion of this where I disagree. Omega-3 and vitamin D are controversial. Personally I think that both are important, especially vitamin D has been shown to significantly increase all-cause mortality. There are so many contradicting studies out there that even meta-analysis will ...